Treatment of hypertension by increasing impaired endothelial TRPV4‐KCa2.3 interaction

Treatment of hypertension by increasing impaired endothelial TRPV4‐KCa2.3 interaction

Abstract The currently available antihypertensive agents have undesirable adverse effects due to systemically altering target activity including receptors, channels, and enzymes. These effects, such as loss of potassium ions induced by diuretics, bronchospasm by beta‐blockers, constipation by Ca2+ c...

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Main Authors: Dongxu He, Qiongxi Pan, Zhen Chen, Chunyuan Sun, Peng Zhang, Aiqin Mao, Yaodan Zhu, Hongjuan Li, Chunxiao Lu, Mingxu Xie, Yin Zhou, Daoming Shen, Chunlei Tang, Zhenyu Yang, Jian Jin, Xiaoqiang Yao, Bernd Nilius, Xin Ma
Format: Article
Language:English
Published: Springer Nature 2017-09-01
Series:EMBO Molecular Medicine
Subjects:
artery
endothelium
hypertension
KCa2.3
TRPV4
Online Access:https://doi.org/10.15252/emmm.201707725
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