Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort

Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort

Objective: This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults. Methods: Data from 45,093 participants in the 1988–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follo...

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Bibliographic Details
Main Authors: Ruitong Liao, Jinzhao Yang, Xiaoping Huang, Yue Xu, Qianqian Ji, Qi Liu, Shan Xu, Peiyi Liu, Yiqiang Zhan
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Experimental Gerontology
Subjects:
Dietary inflammatory index
Alzheimer's disease mortality
National Health Examination Survey
Inflammation
Pro-inflammatory diet
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556525000993
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Summary:Objective: This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults. Methods: Data from 45,093 participants in the 1988–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follow-up through December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AD mortality. Restricted cubic spline analysis explored the non-linear association of DII with AD mortality, and stratified analyses identified higher-risk subgroups. Results: Over a median follow-up of 14.3 years, 455 AD-related deaths occurred. Participants in the highest DII quartile (>2.41) had a 1.50-fold increased risk of AD mortality (95 % CI: 1.12–2.01) compared to the lowest quartile (≤−0.44). Pro-inflammatory diets (DII > 0) were associated with a 44 % higher risk of AD mortality (HR: 1.44, 95 % CI: 1.14–1.81). A dose-response relationship was observed, with increased risks across quartiles, and findings were consistent across demographic and clinical subgroups. Conclusions: Higher DII levels were significantly associated with elevated AD mortality risk, highlighting the potential role of pro-inflammatory diets in AD-related outcomes.
ISSN:1873-6815

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