Breaking barriers: harnessing hypofractionated radiotherapy to transform outcomes in low tumor mutation burden stage III non-small cell lung cancer - a retrospective study

Breaking barriers: harnessing hypofractionated radiotherapy to transform outcomes in low tumor mutation burden stage III non-small cell lung cancer - a retrospective study

BackgroundNon-Small Cell Lung Cancer (NSCLC) patients with low tumor mutational burden (TMB) showed low sensitive to conventional fractionated radiotherapy in our previous study. This study aimed to evaluate the efficacy and safety of hypofractionated radiotherapy (HFRT) in locally advanced NSCLC pa...

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Bibliographic Details
Main Authors: Jingyun Yang, Tianxiang Cui, Yang Zhang, Guangpeng Chen, Xinxin Wang, Jianguo Sun, Anmei Zhang, Guanghui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
non-small cell lung cancer
hypofractionated radiotherapy
conventional fractionated radiotherapy
tumor mutation burden
progression-free survival
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557154/full
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