False Positive Anti-Hepatitis A Virus IgM Result in a Patient with Autoimmune Hepatitis
This report describes a patient with autoimmune hepatitis in whom a positive test result for hepatitis A virus (HAV) IgM antibody led to diagnostic confusion until it was shown to be false positive by immunoprecipitation of IgG from serum. The mechanism for the false positive result may have been re...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/389354 |
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| Summary: | This report describes a patient with autoimmune hepatitis in whom
a positive test result for hepatitis A virus (HAV) IgM antibody led to diagnostic
confusion until it was shown to be false positive by immunoprecipitation of IgG
from serum. The mechanism for the false positive result may have been related to
marked hypergammaglobulinemia, as serum obtained after normalization of immunoglobulin
levels tested negative. However, several other mechanisms were
also considered. This case illustrates that the possibility of false positive results
with the anti-HAV lgM assay should be kept in mind when the clinical features of
the illness are not suggestive of acute hepatitis A. |
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| ISSN: | 0835-7900 |