Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration
Bone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma. In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2016/3452171 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548114420989952 |
|---|---|
| author | Narcisa Mederle Stefania Marin Minodora Maria Marin Elena Danila Ovidiu Mederle Madalina Georgiana Albu Kaya Mihaela Violeta Ghica |
| author_facet | Narcisa Mederle Stefania Marin Minodora Maria Marin Elena Danila Ovidiu Mederle Madalina Georgiana Albu Kaya Mihaela Violeta Ghica |
| author_sort | Narcisa Mederle |
| collection | DOAJ |
| description | Bone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma. In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone composition and prevent or treat infections due to doxycycline content. The biomaterials were obtained by freeze-drying in spongious forms and were characterized by water uptake capacity and microscopy. The in vitro release of doxycycline was also determined and established by non-Fickian drug transport mechanism. Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked. |
| format | Article |
| id | doaj-art-4d4f056537b24f83a3d56d81a7787240 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-4d4f056537b24f83a3d56d81a77872402025-02-03T06:42:11ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422016-01-01201610.1155/2016/34521713452171Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone RegenerationNarcisa Mederle0Stefania Marin1Minodora Maria Marin2Elena Danila3Ovidiu Mederle4Madalina Georgiana Albu Kaya5Mihaela Violeta Ghica6Faculty of Veterinary Medicine, Banat’s University of Agricultural Sciences, 119 Calea Aradului, 300645 Timişoara, RomaniaCollagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, RomaniaCollagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, RomaniaCollagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, RomaniaDepartment of Histology, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babes”, Piata Eftimie Murgu 2, 300041 Timişoara, RomaniaCollagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, RomaniaBone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma. In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone composition and prevent or treat infections due to doxycycline content. The biomaterials were obtained by freeze-drying in spongious forms and were characterized by water uptake capacity and microscopy. The in vitro release of doxycycline was also determined and established by non-Fickian drug transport mechanism. Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked.http://dx.doi.org/10.1155/2016/3452171 |
| spellingShingle | Narcisa Mederle Stefania Marin Minodora Maria Marin Elena Danila Ovidiu Mederle Madalina Georgiana Albu Kaya Mihaela Violeta Ghica Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration Advances in Materials Science and Engineering |
| title | Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration |
| title_full | Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration |
| title_fullStr | Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration |
| title_full_unstemmed | Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration |
| title_short | Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration |
| title_sort | innovative biomaterials based on collagen hydroxyapatite and doxycycline for bone regeneration |
| url | http://dx.doi.org/10.1155/2016/3452171 |
| work_keys_str_mv | AT narcisamederle innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT stefaniamarin innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT minodoramariamarin innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT elenadanila innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT ovidiumederle innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT madalinageorgianaalbukaya innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration AT mihaelavioletaghica innovativebiomaterialsbasedoncollagenhydroxyapatiteanddoxycyclineforboneregeneration |