Role of Matrix Metalloproteinase-8 in Atherosclerosis
Plaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic plaques have been described to be vulnerable and more prone to rupture when they are characterized by thin, highly inflamed, and collagen-poor fibrous caps and contain elevated levels of proteases, including...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/659282 |
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| author | Sébastien Lenglet François Mach Fabrizio Montecucco |
| author_facet | Sébastien Lenglet François Mach Fabrizio Montecucco |
| author_sort | Sébastien Lenglet |
| collection | DOAJ |
| description | Plaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic plaques have been described to be vulnerable and more prone to rupture when they are characterized by thin, highly inflamed, and collagen-poor fibrous caps and contain elevated levels of proteases, including metalloproteinases (MMPs). Initiation of collagen breakdown in plaques requires interstitial collagenases, a MMP subfamily consisting of MMP-1, MMP-8, and MMP-13. Previous reports demonstrated that MMP-1 and MMP-13 might be overexpressed in both human and experimental atherosclerosis. Since neutrophils have been only recently reported in atherosclerotic plaques, the role of MMP-8 (formerly known as “neutrophil collagenase”) was only marginally evaluated. In this paper, we will update and comment on evidence of the most relevant regulatory pathways and activities mediated by MMP-8 in atherogenesis. |
| format | Article |
| id | doaj-art-4d4e22c634644167a5b38c95585f0f54 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4d4e22c634644167a5b38c95585f0f542025-02-03T05:59:19ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/659282659282Role of Matrix Metalloproteinase-8 in AtherosclerosisSébastien Lenglet0François Mach1Fabrizio Montecucco2Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 1211 Geneva 4, SwitzerlandCardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 1211 Geneva 4, SwitzerlandCardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 1211 Geneva 4, SwitzerlandPlaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic plaques have been described to be vulnerable and more prone to rupture when they are characterized by thin, highly inflamed, and collagen-poor fibrous caps and contain elevated levels of proteases, including metalloproteinases (MMPs). Initiation of collagen breakdown in plaques requires interstitial collagenases, a MMP subfamily consisting of MMP-1, MMP-8, and MMP-13. Previous reports demonstrated that MMP-1 and MMP-13 might be overexpressed in both human and experimental atherosclerosis. Since neutrophils have been only recently reported in atherosclerotic plaques, the role of MMP-8 (formerly known as “neutrophil collagenase”) was only marginally evaluated. In this paper, we will update and comment on evidence of the most relevant regulatory pathways and activities mediated by MMP-8 in atherogenesis.http://dx.doi.org/10.1155/2013/659282 |
| spellingShingle | Sébastien Lenglet François Mach Fabrizio Montecucco Role of Matrix Metalloproteinase-8 in Atherosclerosis Mediators of Inflammation |
| title | Role of Matrix Metalloproteinase-8 in Atherosclerosis |
| title_full | Role of Matrix Metalloproteinase-8 in Atherosclerosis |
| title_fullStr | Role of Matrix Metalloproteinase-8 in Atherosclerosis |
| title_full_unstemmed | Role of Matrix Metalloproteinase-8 in Atherosclerosis |
| title_short | Role of Matrix Metalloproteinase-8 in Atherosclerosis |
| title_sort | role of matrix metalloproteinase 8 in atherosclerosis |
| url | http://dx.doi.org/10.1155/2013/659282 |
| work_keys_str_mv | AT sebastienlenglet roleofmatrixmetalloproteinase8inatherosclerosis AT francoismach roleofmatrixmetalloproteinase8inatherosclerosis AT fabriziomontecucco roleofmatrixmetalloproteinase8inatherosclerosis |