Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes
With the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide. Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/978761 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550350195785728 |
|---|---|
| author | Masafumi Ihara Hidekazu Tomimoto |
| author_facet | Masafumi Ihara Hidekazu Tomimoto |
| author_sort | Masafumi Ihara |
| collection | DOAJ |
| description | With the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide. Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly. It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion. Detailed characterization of this model may help to decipher the substrates associated with impaired memory and move toward a more integrated therapy of vascular cognitive impairment. |
| format | Article |
| id | doaj-art-4d4c4e11f8684ecc8a8c56918c46d704 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-4d4c4e11f8684ecc8a8c56918c46d7042025-02-03T06:07:03ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/978761978761Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter ChangesMasafumi Ihara0Hidekazu Tomimoto1Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo, Kyoto 606-8507, JapanDepartment of Neurology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, JapanWith the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide. Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly. It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion. Detailed characterization of this model may help to decipher the substrates associated with impaired memory and move toward a more integrated therapy of vascular cognitive impairment.http://dx.doi.org/10.4061/2011/978761 |
| spellingShingle | Masafumi Ihara Hidekazu Tomimoto Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes Journal of Aging Research |
| title | Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes |
| title_full | Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes |
| title_fullStr | Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes |
| title_full_unstemmed | Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes |
| title_short | Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes |
| title_sort | lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes |
| url | http://dx.doi.org/10.4061/2011/978761 |
| work_keys_str_mv | AT masafumiihara lessonsfromamousemodelcharacterizingfeaturesofvascularcognitiveimpairmentwithwhitematterchanges AT hidekazutomimoto lessonsfromamousemodelcharacterizingfeaturesofvascularcognitiveimpairmentwithwhitematterchanges |