Alanine Aminotransferase Deficiency in a Patient With Hyperferritinemia, Steatosis Hepatis, and Hepatosplenomegaly
The glutamate pyruvate transaminase enzyme, also called alanine aminotransferase (ALT), plays an important role in gluconeogenesis and amino acid metabolism. It catalyzes the reversible transamination of L-alanine and α-ketoglutarate to pyruvate and L-glutamate. ALT is mostly located in the liver bu...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2022-10-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0164 |
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| Summary: | The glutamate pyruvate transaminase enzyme, also called alanine aminotransferase (ALT), plays an important role in gluconeogenesis and amino acid metabolism. It catalyzes the reversible transamination of L-alanine and α-ketoglutarate to pyruvate and L-glutamate. ALT is mostly located in the liver but is also present in other organs like kidney, heart, skeletal muscle, pancreas, and spleen. ALT deficiency was reported in a case of hepatitis B and hepatitis C infection, whereas complete absence of ALT, to our knowledge, has only been reported in 1 case of acute liver failure. |
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| ISSN: | 2767-7664 |