Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features
Background: Breast cancer is categorized into four primary molecular subtypes based on gene expression profiles and hormone receptor status: Luminal A & B subtypes, Basal-like, and HER2-enriched. This study assessed the association of molecular categories of breast carcinoma with the clinicopat...
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ziauddin University
2025-01-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3284 |
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| _version_ | 1832594207586385920 |
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| author | Ambreen Bari Sumayyah Shawana |
| author_facet | Ambreen Bari Sumayyah Shawana |
| author_sort | Ambreen Bari |
| collection | DOAJ |
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Background: Breast cancer is categorized into four primary molecular subtypes based on gene expression profiles and hormone receptor status: Luminal A & B subtypes, Basal-like, and HER2-enriched. This study assessed the association of molecular categories of breast carcinoma with the clinicopathological features.
Method: A cross-sectional study was conducted between January 2022 and August 2024; 200 mastectomy specimens were collected with a non-probability consecutive sampling technique from Ziauddin Hospital Histopathology Department in Karachi, Pakistan. Immunohistochemical analysis was done for ER, PR, HER 2 Neu, and Ki-67 and the findings were statistically analyzed for association with clinicopathological parameters.
Results: Luminal B subtype was found to be the most common subtype. The study identified pT2 and pT3 as the most frequent pathological stages, with 74 cases (38.1%) and 71 cases (34.4%), respectively. Low-grade tumors were less frequent as compared to intermediate and high-grade tumors with 11 (5.5%), 73(36.5%), and 116 cases (58.0%), respectively. A significant association was observed between molecular subtypes and tumor grade, stage, and histological subtypes. However, insignificant association was seen with age, laterality, and tumor site.
Conclusion: Luminal B tumor was the most frequent subtype, while luminal A was the least prevalent. Luminal B tumors were primarily associated with invasive ductal carcinoma invasive ductal carcinoma (NOS). These tumors were commonly found in women aged 41-50. Furthermore, a strong association of molecular subtypes was observed with histological grading and staging.
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| format | Article |
| id | doaj-art-4d256e0416784b4d83c59163a597fe4f |
| institution | Kabale University |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | ziauddin University |
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| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-4d256e0416784b4d83c59163a597fe4f2025-01-19T20:18:29Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-01-0114110.36283/ziun-pjmd14-1/005Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological FeaturesAmbreen Bari0Sumayyah Shawana1Ziauddin University ,Karachi, Pakistan Bahria University Health Sciences, Karachi, Pakistan. Background: Breast cancer is categorized into four primary molecular subtypes based on gene expression profiles and hormone receptor status: Luminal A & B subtypes, Basal-like, and HER2-enriched. This study assessed the association of molecular categories of breast carcinoma with the clinicopathological features. Method: A cross-sectional study was conducted between January 2022 and August 2024; 200 mastectomy specimens were collected with a non-probability consecutive sampling technique from Ziauddin Hospital Histopathology Department in Karachi, Pakistan. Immunohistochemical analysis was done for ER, PR, HER 2 Neu, and Ki-67 and the findings were statistically analyzed for association with clinicopathological parameters. Results: Luminal B subtype was found to be the most common subtype. The study identified pT2 and pT3 as the most frequent pathological stages, with 74 cases (38.1%) and 71 cases (34.4%), respectively. Low-grade tumors were less frequent as compared to intermediate and high-grade tumors with 11 (5.5%), 73(36.5%), and 116 cases (58.0%), respectively. A significant association was observed between molecular subtypes and tumor grade, stage, and histological subtypes. However, insignificant association was seen with age, laterality, and tumor site. Conclusion: Luminal B tumor was the most frequent subtype, while luminal A was the least prevalent. Luminal B tumors were primarily associated with invasive ductal carcinoma invasive ductal carcinoma (NOS). These tumors were commonly found in women aged 41-50. Furthermore, a strong association of molecular subtypes was observed with histological grading and staging. https://ojs.zu.edu.pk/pjmd/article/view/3284Molecular SubtypesBreast CancerClinicopathological Features |
| spellingShingle | Ambreen Bari Sumayyah Shawana Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features Pakistan Journal of Medicine and Dentistry Molecular Subtypes Breast Cancer Clinicopathological Features |
| title | Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features |
| title_full | Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features |
| title_fullStr | Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features |
| title_full_unstemmed | Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features |
| title_short | Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features |
| title_sort | molecular subtypes of breast carcinoma and their association with clinicopathological features |
| topic | Molecular Subtypes Breast Cancer Clinicopathological Features |
| url | https://ojs.zu.edu.pk/pjmd/article/view/3284 |
| work_keys_str_mv | AT ambreenbari molecularsubtypesofbreastcarcinomaandtheirassociationwithclinicopathologicalfeatures AT sumayyahshawana molecularsubtypesofbreastcarcinomaandtheirassociationwithclinicopathologicalfeatures |