Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature
Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/7178065 |
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| author | Carolina Afonso Adriana Roque Cátia Almeida Maria Beatriz Pimentão Maria José Julião Rodolfo Silva Catarina Geraldes Marília Gomes |
| author_facet | Carolina Afonso Adriana Roque Cátia Almeida Maria Beatriz Pimentão Maria José Julião Rodolfo Silva Catarina Geraldes Marília Gomes |
| author_sort | Carolina Afonso |
| collection | DOAJ |
| description | Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy. |
| format | Article |
| id | doaj-art-4d246fcaa58340c99691b9c197040db5 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4d246fcaa58340c99691b9c197040db52025-02-03T01:22:57ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/7178065Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the LiteratureCarolina Afonso0Adriana Roque1Cátia Almeida2Maria Beatriz Pimentão3Maria José Julião4Rodolfo Silva5Catarina Geraldes6Marília Gomes7Hematology UnitHematology UnitHematology UnitPathology UnitPathology UnitNuclear Medicine UnitHematology UnitHematology UnitIatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.http://dx.doi.org/10.1155/2022/7178065 |
| spellingShingle | Carolina Afonso Adriana Roque Cátia Almeida Maria Beatriz Pimentão Maria José Julião Rodolfo Silva Catarina Geraldes Marília Gomes Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature |
| title_full | Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature |
| title_fullStr | Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature |
| title_full_unstemmed | Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature |
| title_short | Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature |
| title_sort | methotrexate associated lymphoproliferative disorder in a patient with psoriasis a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2022/7178065 |
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