The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma
Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-geno...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | Gynecology and Obstetrics Clinical Medicine |
| Online Access: | https://gocm.bmj.com/content/4/1/e000012.full |
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| author | Jingyi Zhou Jianliu Wang Xuerun Liu |
| author_facet | Jingyi Zhou Jianliu Wang Xuerun Liu |
| author_sort | Jingyi Zhou |
| collection | DOAJ |
| description | Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer. |
| format | Article |
| id | doaj-art-4d1f59f3369f4ad0b29915f3052e3342 |
| institution | Kabale University |
| issn | 2097-0587 2667-1646 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Gynecology and Obstetrics Clinical Medicine |
| spelling | doaj-art-4d1f59f3369f4ad0b29915f3052e33422025-01-19T06:15:08ZengBMJ Publishing GroupGynecology and Obstetrics Clinical Medicine2097-05872667-16462024-04-014110.1136/gocm-2024-000012The role of oestrogen and oestrogen-calcium axis in endometrial carcinomaJingyi Zhou0Jianliu Wang1Xuerun Liu2Department of Obstetrics and Gynecology, Peking University People`s Hospital, Beijing 100044, ChinaDepartment of Obstetrics and Gynecology, Peking University People`s Hospital, Beijing 100044, ChinaDepartment of Obstetrics and Gynecology, Peking University People`s Hospital, Beijing 100044, ChinaUnopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer.https://gocm.bmj.com/content/4/1/e000012.full |
| spellingShingle | Jingyi Zhou Jianliu Wang Xuerun Liu The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma Gynecology and Obstetrics Clinical Medicine |
| title | The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma |
| title_full | The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma |
| title_fullStr | The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma |
| title_full_unstemmed | The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma |
| title_short | The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma |
| title_sort | role of oestrogen and oestrogen calcium axis in endometrial carcinoma |
| url | https://gocm.bmj.com/content/4/1/e000012.full |
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