Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma
Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex horm...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/854530 |
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| author | Maurizio Montella Giovanni D’Arena Anna Crispo Mario Capunzo Flavia Nocerino Maria Grimaldi Antonio Barbieri Anna Maria D’Ursi Mario Felice Tecce Alfonso Amore Massimiliano Galdiero Gennaro Ciliberto Aldo Giudice |
| author_facet | Maurizio Montella Giovanni D’Arena Anna Crispo Mario Capunzo Flavia Nocerino Maria Grimaldi Antonio Barbieri Anna Maria D’Ursi Mario Felice Tecce Alfonso Amore Massimiliano Galdiero Gennaro Ciliberto Aldo Giudice |
| author_sort | Maurizio Montella |
| collection | DOAJ |
| description | Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC. While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels. Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue. This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections. Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases. |
| format | Article |
| id | doaj-art-4d1c418e705149c2a47d6ba2d159c18c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4d1c418e705149c2a47d6ba2d159c18c2025-02-03T01:26:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/854530854530Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular CarcinomaMaurizio Montella0Giovanni D’Arena1Anna Crispo2Mario Capunzo3Flavia Nocerino4Maria Grimaldi5Antonio Barbieri6Anna Maria D’Ursi7Mario Felice Tecce8Alfonso Amore9Massimiliano Galdiero10Gennaro Ciliberto11Aldo Giudice12Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDepartment of Onco-Hematology, IRCCS, Cancer Referral Center of Basilicata, 85028 Rionero in Vulture, ItalyEpidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDepartment of Medicine and Surgery, University of Salerno, 84081 Fisciano, ItalyEpidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyEpidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyAnimal Facility, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, ItalyDepartment of Surgery, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDepartment of Experimental Medicine, II University of Naples, 81055 Naples, ItalyNational Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyEpidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyInfection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC. While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels. Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue. This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections. Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases.http://dx.doi.org/10.1155/2015/854530 |
| spellingShingle | Maurizio Montella Giovanni D’Arena Anna Crispo Mario Capunzo Flavia Nocerino Maria Grimaldi Antonio Barbieri Anna Maria D’Ursi Mario Felice Tecce Alfonso Amore Massimiliano Galdiero Gennaro Ciliberto Aldo Giudice Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma International Journal of Endocrinology |
| title | Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_full | Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_fullStr | Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_full_unstemmed | Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_short | Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_sort | role of sex hormones in the development and progression of hepatitis b virus associated hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2015/854530 |
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