Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient
Patients with inflammatory bowel disease (IBD) are at risk of developing malnutrition, severe dystrophic muscle weakness, and muscle atrophy. We present a case of a 33-year-old male patient who exhibited concurrent muscle atrophy, muscle weakness, diarrhea, and mucopurulent bloody stools. Notably, t...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1481780/full |
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| author | Limin Li Qiong Yan Mingming Deng Muhan Lü Tiejun Zhou Xiaolin Zhong |
| author_facet | Limin Li Qiong Yan Mingming Deng Muhan Lü Tiejun Zhou Xiaolin Zhong |
| author_sort | Limin Li |
| collection | DOAJ |
| description | Patients with inflammatory bowel disease (IBD) are at risk of developing malnutrition, severe dystrophic muscle weakness, and muscle atrophy. We present a case of a 33-year-old male patient who exhibited concurrent muscle atrophy, muscle weakness, diarrhea, and mucopurulent bloody stools. Notably, the patient reported that his household or family members experienced similar symptoms of muscle weakness, without any apparent neurological or psychiatric manifestations. The patient’s intestinal symptoms were most consistent with ulcerative colitis, while the muscle weakness originated from dysferlinopathy following a comprehensive diagnostic work-up. The patient was initiated on vedolizumab therapy and L-carnitine therapy, and his symptoms improved after 1 month of follow-up. This case study underscores the necessity for clinicians to maintain a high level of suspicion for the presence of concomitant diseases when encountering IBD patients with muscle weakness. This approach is essential for achieving an early diagnosis and treatment. |
| format | Article |
| id | doaj-art-4d1251ef38fb4a538eb194dd4e56cc05 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-4d1251ef38fb4a538eb194dd4e56cc052025-01-22T07:14:35ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14817801481780Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patientLimin Li0Qiong Yan1Mingming Deng2Muhan Lü3Tiejun Zhou4Xiaolin Zhong5Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaPatients with inflammatory bowel disease (IBD) are at risk of developing malnutrition, severe dystrophic muscle weakness, and muscle atrophy. We present a case of a 33-year-old male patient who exhibited concurrent muscle atrophy, muscle weakness, diarrhea, and mucopurulent bloody stools. Notably, the patient reported that his household or family members experienced similar symptoms of muscle weakness, without any apparent neurological or psychiatric manifestations. The patient’s intestinal symptoms were most consistent with ulcerative colitis, while the muscle weakness originated from dysferlinopathy following a comprehensive diagnostic work-up. The patient was initiated on vedolizumab therapy and L-carnitine therapy, and his symptoms improved after 1 month of follow-up. This case study underscores the necessity for clinicians to maintain a high level of suspicion for the presence of concomitant diseases when encountering IBD patients with muscle weakness. This approach is essential for achieving an early diagnosis and treatment.https://www.frontiersin.org/articles/10.3389/fmed.2024.1481780/fullulcerative colitisdysferlinopathyDYSF mutationmuscle weaknesscase report |
| spellingShingle | Limin Li Qiong Yan Mingming Deng Muhan Lü Tiejun Zhou Xiaolin Zhong Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient Frontiers in Medicine ulcerative colitis dysferlinopathy DYSF mutation muscle weakness case report |
| title | Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient |
| title_full | Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient |
| title_fullStr | Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient |
| title_full_unstemmed | Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient |
| title_short | Case report: A co-existing case of ulcerative colitis and dysferlinopathy in a male patient |
| title_sort | case report a co existing case of ulcerative colitis and dysferlinopathy in a male patient |
| topic | ulcerative colitis dysferlinopathy DYSF mutation muscle weakness case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1481780/full |
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