Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application
Reprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body of research is concent...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| author | Ziyuan Liang Lixian Deng Xiaoying Zhou Zhe Zhang Weilin Zhao |
| author_facet | Ziyuan Liang Lixian Deng Xiaoying Zhou Zhe Zhang Weilin Zhao |
| author_sort | Ziyuan Liang |
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| description | Reprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body of research is concentrating on the metabolism of KBs within tumors, investigating their roles as signaling mediators, drivers of post-translational modifications, and regulators of inflammation and oxidative stress. The ketogenic diet (KD) may enhance the sensitivity of various cancers to standard therapies, such as chemotherapy and radiotherapy, by exploiting the reprogrammed metabolism of cancer cells and shifting the metabolic state from glucose reliance to KB utilization, rendering it a promising candidate for adjunct cancer therapy. Nonetheless, numerous questions remain regarding the expression of key metabolic genes across different tumors, the regulation of their activities, and the impact of individual KBs on various tumor types. Further investigation is imperative to resolve the conflicting data concerning KB synthesis and functionality within tumors. This review aims to encapsulate the intricate roles of KBs in cancer metabolism, elucidating a comprehensive grasp of their mechanisms and highlighting emerging clinical applications, thereby setting the stage for future investigations into their therapeutic potential. |
| format | Article |
| id | doaj-art-4d1003a22beb482ba4a0f73a547a041b |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-4d1003a22beb482ba4a0f73a547a041b2025-01-24T13:24:25ZengMDPI AGBiomedicines2227-90592025-01-0113121010.3390/biomedicines13010210Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and ApplicationZiyuan Liang0Lixian Deng1Xiaoying Zhou2Zhe Zhang3Weilin Zhao4Key Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, ChinaKey Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, ChinaKey Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaReprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body of research is concentrating on the metabolism of KBs within tumors, investigating their roles as signaling mediators, drivers of post-translational modifications, and regulators of inflammation and oxidative stress. The ketogenic diet (KD) may enhance the sensitivity of various cancers to standard therapies, such as chemotherapy and radiotherapy, by exploiting the reprogrammed metabolism of cancer cells and shifting the metabolic state from glucose reliance to KB utilization, rendering it a promising candidate for adjunct cancer therapy. Nonetheless, numerous questions remain regarding the expression of key metabolic genes across different tumors, the regulation of their activities, and the impact of individual KBs on various tumor types. Further investigation is imperative to resolve the conflicting data concerning KB synthesis and functionality within tumors. This review aims to encapsulate the intricate roles of KBs in cancer metabolism, elucidating a comprehensive grasp of their mechanisms and highlighting emerging clinical applications, thereby setting the stage for future investigations into their therapeutic potential.https://www.mdpi.com/2227-9059/13/1/210tumorketone bodiesmetabolismketogenic diettherapeutic approach |
| spellingShingle | Ziyuan Liang Lixian Deng Xiaoying Zhou Zhe Zhang Weilin Zhao Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application Biomedicines tumor ketone bodies metabolism ketogenic diet therapeutic approach |
| title | Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application |
| title_full | Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application |
| title_fullStr | Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application |
| title_full_unstemmed | Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application |
| title_short | Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application |
| title_sort | comprehensive overview of ketone bodies in cancer metabolism mechanisms and application |
| topic | tumor ketone bodies metabolism ketogenic diet therapeutic approach |
| url | https://www.mdpi.com/2227-9059/13/1/210 |
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