Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?
Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2014/695014 |
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| author | Hadis Sabour Abbas Norouzi Javidan Sahar Latifi Mohammad Reza Hadian Seyed-Hassan Emami Razavi Farzad Shidfar Mohammad Reza Vafa Hamidreza Aghaei Meybodi |
| author_facet | Hadis Sabour Abbas Norouzi Javidan Sahar Latifi Mohammad Reza Hadian Seyed-Hassan Emami Razavi Farzad Shidfar Mohammad Reza Vafa Hamidreza Aghaei Meybodi |
| author_sort | Hadis Sabour |
| collection | DOAJ |
| description | Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r=0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r=-0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation. |
| format | Article |
| id | doaj-art-4d0baa9bbc684e29a774f01b733388f9 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-4d0baa9bbc684e29a774f01b733388f92025-02-03T05:44:00ZengWileyJournal of Osteoporosis2090-80592042-00642014-01-01201410.1155/2014/695014695014Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?Hadis Sabour0Abbas Norouzi Javidan1Sahar Latifi2Mohammad Reza Hadian3Seyed-Hassan Emami Razavi4Farzad Shidfar5Mohammad Reza Vafa6Hamidreza Aghaei Meybodi7Brain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, IranBrain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, IranBrain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, IranBrain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, IranBrain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, IranNutrition Department, Iran University of Medical Sciences, Tehran, IranNutrition Department, Iran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, IranPurpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r=0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r=-0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.http://dx.doi.org/10.1155/2014/695014 |
| spellingShingle | Hadis Sabour Abbas Norouzi Javidan Sahar Latifi Mohammad Reza Hadian Seyed-Hassan Emami Razavi Farzad Shidfar Mohammad Reza Vafa Hamidreza Aghaei Meybodi Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? Journal of Osteoporosis |
| title | Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? |
| title_full | Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? |
| title_fullStr | Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? |
| title_full_unstemmed | Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? |
| title_short | Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? |
| title_sort | is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury |
| url | http://dx.doi.org/10.1155/2014/695014 |
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