Accurate prediction of virulence factors using pre-train protein language model and ensemble learning

Accurate prediction of virulence factors using pre-train protein language model and ensemble learning

Abstract Background As bacterial pathogens develop increasing resistance to antibiotics, strategies targeting virulence factors (VFs) have emerged as a promising and effective approach for treating bacterial infections. Existing methods mainly relied on sequence similarity, and remote homology relat...

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Bibliographic Details
Main Authors: Guanghui Li, Jian Zhou, Jiawei Luo, Cheng Liang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Virulence factor prediction
Protein language model
Ensemble learning
TM-score
Remote homology
Online Access:https://doi.org/10.1186/s12864-025-11694-8
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