Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis
The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/1094352 |
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| author | Tábata Cristina do Carmo Almeida Francisco Winter dos Santos Figueiredo Valter Cordeiro Barbosa Filho Luiz Carlos de Abreu Fernando Luiz Affonso Fonseca Fernando Adami |
| author_facet | Tábata Cristina do Carmo Almeida Francisco Winter dos Santos Figueiredo Valter Cordeiro Barbosa Filho Luiz Carlos de Abreu Fernando Luiz Affonso Fonseca Fernando Adami |
| author_sort | Tábata Cristina do Carmo Almeida |
| collection | DOAJ |
| description | The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in six databases to identify randomized controlled trials with the criteria: humans older than 18 years (adults), use of TENS in the experimental group, and having at least one pre- and postintervention blood level of at least one proinflammatory cytokine. The risk of bias and the level of evidence were assessed. Five studies were included involving 240 participants. The heterogeneity of the studies was high (I2: 85%); therefore, we used a random-effects meta-analysis. It was observed through the meta-analysis synthesis measures that there were statistically significant differences following the use of TENS to reduce the general group of cytokines. When grouped by chronic disease, by postoperative settings, or by individual studies in the case of IL-6, it was observed that the significant reduction of cytokines related to the use of TENS was maintained. The use of TENS reduced the blood levels of proinflammatory cytokines (we observed a protective factor of TENS in relation to inflammation). The protocol of the systematic review was registered in PROSPERO, CRD42017060379. |
| format | Article |
| id | doaj-art-4d03206827e84d36b6a6ca5b782fb677 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4d03206827e84d36b6a6ca5b782fb6772025-02-03T05:44:00ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/10943521094352Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-AnalysisTábata Cristina do Carmo Almeida0Francisco Winter dos Santos Figueiredo1Valter Cordeiro Barbosa Filho2Luiz Carlos de Abreu3Fernando Luiz Affonso Fonseca4Fernando Adami5Epidemiology and Data Analysis Laboratory, ABC Medical School (FMABC), Av. Lauro Gomes 2000, Vila Sacadura Cabral, Santo André, 09060-870 São Paulo, SP, BrazilEpidemiology and Data Analysis Laboratory, ABC Medical School (FMABC), Av. Lauro Gomes 2000, Vila Sacadura Cabral, Santo André, 09060-870 São Paulo, SP, BrazilFederal Institute of Education, Science and Technology of Ceara, Boa Viagem Campus, Rod. Pres. Juscelino Kubitschek, 63870-000 Boa Viagem, CE, BrazilStudy Design and Scientific Writing Laboratory, ABC Medical School (FMABC), Av. Lauro Gomes 2000, Vila Sacadura Cabral, Santo André, 09060-870 São Paulo, SP, BrazilClinical Laboratory, ABC Medical School (FMABC), Av. Lauro Gomes 2000, Vila Sacadura Cabral, Santo André, 09060-870 São Paulo, SP, BrazilEpidemiology and Data Analysis Laboratory, ABC Medical School (FMABC), Av. Lauro Gomes 2000, Vila Sacadura Cabral, Santo André, 09060-870 São Paulo, SP, BrazilThe mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in six databases to identify randomized controlled trials with the criteria: humans older than 18 years (adults), use of TENS in the experimental group, and having at least one pre- and postintervention blood level of at least one proinflammatory cytokine. The risk of bias and the level of evidence were assessed. Five studies were included involving 240 participants. The heterogeneity of the studies was high (I2: 85%); therefore, we used a random-effects meta-analysis. It was observed through the meta-analysis synthesis measures that there were statistically significant differences following the use of TENS to reduce the general group of cytokines. When grouped by chronic disease, by postoperative settings, or by individual studies in the case of IL-6, it was observed that the significant reduction of cytokines related to the use of TENS was maintained. The use of TENS reduced the blood levels of proinflammatory cytokines (we observed a protective factor of TENS in relation to inflammation). The protocol of the systematic review was registered in PROSPERO, CRD42017060379.http://dx.doi.org/10.1155/2018/1094352 |
| spellingShingle | Tábata Cristina do Carmo Almeida Francisco Winter dos Santos Figueiredo Valter Cordeiro Barbosa Filho Luiz Carlos de Abreu Fernando Luiz Affonso Fonseca Fernando Adami Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis Mediators of Inflammation |
| title | Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis |
| title_full | Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis |
| title_fullStr | Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis |
| title_short | Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis |
| title_sort | effects of transcutaneous electrical nerve stimulation on proinflammatory cytokines systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/1094352 |
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