Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins
The aim of the review is to summarize contemporary views on mechanisms of the systemic inflammation in patients with coronary heart disease after coronary artery bypass grafting (CABG). The information about the prognostic value of activation of the inflammatory markers, such as C-reactive protein (...
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| Format: | Article |
| Language: | English |
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TOV Chetverta Khvylia
2016-03-01
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| Series: | Кардіохірургія та інтервенційна кардіологія |
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| Online Access: | http://csic.com.ua/images/pdf/2016/1-2016/markery-vospaleniya-do-i-posle-aortokoronarnogo-shuntirovaniya.pdf |
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| author | O.J. Zharinov O.A. Yepanchintseva I.V. Shklianka A.I. Kurchenko B.M. Todurov |
| author_facet | O.J. Zharinov O.A. Yepanchintseva I.V. Shklianka A.I. Kurchenko B.M. Todurov |
| author_sort | O.J. Zharinov |
| collection | DOAJ |
| description | The aim of the review is to summarize contemporary views on mechanisms of the systemic inflammation in patients with coronary heart disease after coronary artery bypass grafting (CABG). The information about the prognostic value of activation of the inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) is provided. It is shown that elevated levels of high-sensitive CRP before CABG and high levels of TNF and IL-6 during postoperation period may be associated with hemodynamic disorders and increasing the frequency of early complications and more likely occurrence of restenosis at long-term follow-up. Therefore, the study of inflammatory markers may provide valuable information about short- and long-term prognosis after CABG. Statin medications reveal highly anti-inflammatory activity and reduce the risk of coronary events and atrial fibrillation after CABG surgery. The use of statins before and after revascularization surgery reduces the risk of acute coronary syndrome and the level of perioperative mortality by 30–42 %, and is effective for the prevention of complications within one year after CABG surgery. |
| format | Article |
| id | doaj-art-4cf9e8b2250841d684f77cc47e10b479 |
| institution | Kabale University |
| issn | 2305-3127 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | TOV Chetverta Khvylia |
| record_format | Article |
| series | Кардіохірургія та інтервенційна кардіологія |
| spelling | doaj-art-4cf9e8b2250841d684f77cc47e10b4792025-02-02T16:03:38ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272016-03-011 (12)512Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statinsO.J. Zharinov0O.A. Yepanchintseva1I.V. Shklianka2A.I. Kurchenko3B.M. Todurov4Shupyk National Medical Academy of Postgraduate Education of Healthcare Ministry of Ukraine, Kyiv, UkraineHeart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineHeart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineO.O. Bogomolets National Medical University, Kyiv, UkraineHeart Institute of Healthcare Ministry of Ukraine, Kyiv, UkraineThe aim of the review is to summarize contemporary views on mechanisms of the systemic inflammation in patients with coronary heart disease after coronary artery bypass grafting (CABG). The information about the prognostic value of activation of the inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor (TNF) is provided. It is shown that elevated levels of high-sensitive CRP before CABG and high levels of TNF and IL-6 during postoperation period may be associated with hemodynamic disorders and increasing the frequency of early complications and more likely occurrence of restenosis at long-term follow-up. Therefore, the study of inflammatory markers may provide valuable information about short- and long-term prognosis after CABG. Statin medications reveal highly anti-inflammatory activity and reduce the risk of coronary events and atrial fibrillation after CABG surgery. The use of statins before and after revascularization surgery reduces the risk of acute coronary syndrome and the level of perioperative mortality by 30–42 %, and is effective for the prevention of complications within one year after CABG surgery.http://csic.com.ua/images/pdf/2016/1-2016/markery-vospaleniya-do-i-posle-aortokoronarnogo-shuntirovaniya.pdfcoronary artery bypass graftingsystemic inflammation |
| spellingShingle | O.J. Zharinov O.A. Yepanchintseva I.V. Shklianka A.I. Kurchenko B.M. Todurov Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins Кардіохірургія та інтервенційна кардіологія coronary artery bypass grafting systemic inflammation |
| title | Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| title_full | Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| title_fullStr | Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| title_full_unstemmed | Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| title_short | Markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| title_sort | markers of inflammation before and after coronary artery bypass grafting and the effectiveness of statins |
| topic | coronary artery bypass grafting systemic inflammation |
| url | http://csic.com.ua/images/pdf/2016/1-2016/markery-vospaleniya-do-i-posle-aortokoronarnogo-shuntirovaniya.pdf |
| work_keys_str_mv | AT ojzharinov markersofinflammationbeforeandaftercoronaryarterybypassgraftingandtheeffectivenessofstatins AT oayepanchintseva markersofinflammationbeforeandaftercoronaryarterybypassgraftingandtheeffectivenessofstatins AT ivshklianka markersofinflammationbeforeandaftercoronaryarterybypassgraftingandtheeffectivenessofstatins AT aikurchenko markersofinflammationbeforeandaftercoronaryarterybypassgraftingandtheeffectivenessofstatins AT bmtodurov markersofinflammationbeforeandaftercoronaryarterybypassgraftingandtheeffectivenessofstatins |