Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents: A Synergistic Experimental and Structure-Based Virtual Screening

Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents: A Synergistic Experimental and Structure-Based Virtual Screening

A new class of pharmacologically active mixed-ligand complexes (1a-2a) [MII(L)2 (bpy)], where L = 2-(4-morpholinobenzylideneamino)phenol), bpy = 2,2′-bipyridine, MII = Cu (1a), and Zn (2a), were assigned an octahedral geometry by analytical and spectral measurements. Gel electrophoresis showed that...

Full description

Saved in:

Bibliographic Details
Main Authors:	Karunganathan Sakthikumar, Rui Werner Maçedo Krause, Bienfait Kabuyaya Isamura
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Bioinorganic Chemistry and Applications
Online Access:	http://dx.doi.org/10.1155/2022/6987806
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Molecular Architectures Derived from Metal Ions and the Flexible 3,3′-Bipyridine Ligand: Unexpected Dimer with Hg(II)
by: Anupam Khutia, et al.
Published: (2010-01-01)

Synthesis and Characterization of the Adducts of Morpholinedithioccarbamate Complexes of Oxovanadium (IV), Nickel(II), and Copper(II) with Piperidine and Morpholine
by: Mousami Sharma, et al.
Published: (2012-01-01)

Crystal structure of chlorido-(η6-toluene)(2,2′-bipyridine-κ2N,N′)ruthenium(II) hexafluorophosphate, C17H16ClN2RuPF6
by: Gichumbi Joel M., et al.
Published: (2022-08-01)

A New Ruthenium Sensitizer Containing Benzo[1,9]quinolizino(acridin-2-yl)vinyl-2,2′-bipyridine Ligand for Effective Nanocrystalline Dye-Sensitized Solar Cells
by: Jeum-Jong Kim, et al.
Published: (2012-01-01)

The crystal structure of [bis(2,2′-bipyridine-6-carboxylato-κ3N,N,O)magnesium(II)]dihydrate, C22H18N4O6Mg
by: Xi-Shi Tai, et al.
Published: (2023-10-01)

Crystal structure of triaqua-(5-bromoisophthalato-κ1 O)-(2,2′-bipyridine-κ2 N:N′)nickel(II) hydrate, C18H19BrN2NiO8
by: Shi Zhen-Zhen, et al.
Published: (2023-08-01)

The crystal structure of (2,2′-bipyridine-κ2N,N′)- bis(6-phenylpyridine-2-carboxylate-κ2N,O)manganese(II)] monohydrate, C34H26N4O5Mn
by: Tai Xi-Shi, et al.
Published: (2022-08-01)

Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence
by: Priyanka, et al.
Published: (2025-01-01)

Preparation and Antibacterial Activity of Mixed Ligand Complexes of Co(II), Ni(II), Cu(II) and Cd(II) Derived from 1-Phenylazo-2-naphthol and Salicylaldehyde
by: S. A. I. Sharif, et al.
Published: (2011-01-01)

Stability Constants of Mixed Ligand Complexes of Transition Metal(II) Ions with N-(2-Hydroxy-1-naphthylidene)-2,6-diisopropylaniline as Primary Ligand and N-(2-Hydroxybenzylidene)-2,3-dimethylaniline as Secondary Ligand
by: A. K. Mapari, et al.
Published: (2011-01-01)

Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action
by: Jana Kasparkova, et al.
Published: (2022-01-01)

Physicochemical, Spectral, and Biological Studies of Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) Compounds with Ligand Containing Thiazolidin-4-one Moiety
by: Dinesh Kumar, et al.
Published: (2014-01-01)

The crystal structure of [(2,2′-bipyridine-6-carboxylato-κ3 N,N,O)-(6-phenylpyridine-2-carboxylate-κ2 N,O)copper(II)] monohydrate, C23H17N3O5Cu
by: Zeng-Bing Zhao, et al.
Published: (2023-08-01)

The crystal structure of catena-poly[aqua-2,2′bipyridine-κ2N,N′-(μ2-5-ethoxyisophthalato-κ 4O,O′:Oʺ,O′ʺ)cadmium(II)] monohydrate, C20H20CdN2O7
by: Zhang Lilei, et al.
Published: (2022-08-01)

Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent
by: Baraa Mohammed Yaseen, et al.
Published: (2025-01-01)

Cr(III),Mn(II),Fe(III),Co(II),Ni(II),Cu(II) and Zn(II) Complexes with Diisobutyldithiocarbamato Ligand
by: Mohammad Tarique
Published: (2011-01-01)

Synthesis and Study of the Physical and Photovoltaic Properties of Novel Heteroleptic Ruthenium(II) Complexes Ligated with Highly π-Conjugated Bipyridine Ancillary and Phenanthroline Anchoring Ligand for Dye-Sensitized Solar Cells
by: Hyejeong Lee, et al.
Published: (2021-01-01)

Synthesis, Crystal Structure, Spectroscopic Properties, and Interaction with Ct-DNA of Zn(II) with 2-Aminoethanethiol Hydrochloride Ligand
by: Xu-gang Shu, et al.
Published: (2016-01-01)

Ultrasonicated Synthesis of N-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation
by: B. Jayachandra Reddy, et al.
Published: (2010-01-01)

Crystal structure of the nickel(II) complex aqua-(2,6-di(pyrazin-2-yl)-4,4′-bipyridine-κ3 N,N′,N′′)-(phthalato-κ2 O,O′)nickel(II) tetrahydrate, C26H26N6O9Ni
by: Yu-Fang Wang, et al.
Published: (2021-09-01)

Preparation and Study of Some Mn(II), Co(II), Ni(II), Cu(II), Cd(II) and Pb(II) Complexes Containing Heterocyclic Nitrogen Donor Ligands
by: Shayma A. Shaker
Published: (2010-01-01)

Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)
by: A. K. Mapari, et al.
Published: (2011-01-01)

Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand
by: Huilu Wu, et al.
Published: (2012-01-01)

Methyl 2-amino-4-(morpholin-4-yl)benzo[d]thiazole-6-carboxylate tetartohydrate
by: Erik Uran, et al.
Published: (2025-01-01)

Preparation and Spectral Properties of Mixed-Ligand Complexes of VO(IV), Ni(II), Zn(II), Pd(II), Cd(II) and Pb(II) with Dimethylglyoxime and N-acetylglycine
by: Shayma A. Shaker
Published: (2010-01-01)

Biomolecular Networks for Complex Diseases
by: Fang-Xiang Wu, et al.
Published: (2018-01-01)

The Diophantine equation x2+2k=yn, II
by: J. H. E. Cohn
Published: (1999-01-01)

Inhibiting Properties of Morpholine as Corrosion Inhibitor for Mild Steel in 2N Sulphuric Acid and Phosphoric Acid Medium
by: K. Jayanthi, et al.
Published: (2012-01-01)

Crystal structure of (μ2-1-(4,4′-bipyridine-κ2N:N′)-bis[diaqua-(4-iodopyridine-2,6-dicarboxylato-κ3O,N,O′)–cobalt(II)], C24H20Co2I2N4O12
by: Hong Dong-Feng, et al.
Published: (2023-10-01)

Crystal and Molecular Structure of Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) Complex
by: Hakan Arslan, et al.
Published: (2011-01-01)

Stability Constants of Mixed Ligand Complexes of Cu(II) and Ni(II) with Some Amino Acids and Phosphates
by: Aruna Adam, et al.
Published: (2011-01-01)

The crystal structure of (bromido, chlorido)-tricarbonyl-(5,5′-dimethyl-2,2′-bipyridine)-rhenium(I), C15H12Br0.2Cl0.8N2O3Re1
by: Moherane Lehlohonolo, et al.
Published: (2023-10-01)

Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes
by: Snežana Rajković, et al.
Published: (2018-01-01)

Low-Intensity Light-Responsive Anticancer Activity of Platinum(II) Complex Nanocolloids on 2D and 3D In Vitro Cancer Cell Model
by: Viviana Vergaro, et al.
Published: (2022-01-01)

The crystal structure of [μ-hydroxido-bis[(5,5′-dimethyl-2,2′-bipyridine-κ2N,N′)-tricarbonylrhenium(I)] bromide hemihydrate, C30H26N4O9Re2Br
by: Moherane Lehlohonolo, et al.
Published: (2021-09-01)

Synthesis and Characterization of Some Ni(II) and Cu(II) Complexes with 2-[(4-Aminophenyl)imino]-1, 2-diphenyl-1-ethanone
by: K. M. Khalifa, et al.
Published: (2010-01-01)

Synthesis and Photophysical and Electrochemical Properties of Functionalized Mono-, Bis-, and Trisanthracenyl Bridged Ru(II) Bis(2,2′:6′,2″-terpyridine) Charge Transfer Complexes
by: Adewale O. Adeloye, et al.
Published: (2014-01-01)

The crystal structure of fac-tricarbonyl(6-bromo-2,2-bipyridine-κ2 N,N)-(nitrato-κO)rhenium(I), C13H7BrN3O6Re
by: Mkhatshwa Marcus, et al.
Published: (2023-08-01)

Synthesis and Characterization of 2-(Hydroxyimino)-1-(phenylpropylidene)thiocarbonohydrazide and its Metal Complexes with Co(II), Ni(II) and Cu(II) Ions
by: A. Venkatchallam, et al.
Published: (2009-01-01)

Synthesis, Characterization, Cyclic Voltammetry, and Biological Studies of Co(II), Ni(II), and Cu(II) Complexes of a Tridentate Schiff Base, 1-((E)-(2-Mercaptophenylimino) Methyl) Naphthalen-2-ol (H2L1)
by: Maurice Kuate, et al.
Published: (2020-01-01)