Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor
An 18-year-old French Canadian student presenting with a severe normocytic anemia, had undetectable serum cobalamin but normal gastric acidity and no evidence of generalized malabsorption. The gastric juice contained a normal quantity of intrinsic factor. Serum anti-intrinsic factor blocking antibod...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/748604 |
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| _version_ | 1832554080249053184 |
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| author | Jeanne Drouin Nadia Mikhael |
| author_facet | Jeanne Drouin Nadia Mikhael |
| author_sort | Jeanne Drouin |
| collection | DOAJ |
| description | An 18-year-old French Canadian student presenting with a severe
normocytic anemia, had undetectable serum cobalamin but normal gastric acidity
and no evidence of generalized malabsorption. The gastric juice contained a normal
quantity of intrinsic factor. Serum anti-intrinsic factor blocking antibodies were not
present. Absorption of radiolabelled cobalamin given orally in the Schilling test was
decreased but this was corrected by using hog intrinsic factor. Patient gastric juice
bound cobalamin normally but did not promote uptake of this vitamin by homogenates
of guinea pig intestinal mucosa. A family study showed normal cobalamin
absorption for all tested subjects, as well as two α-hemoglobin gene deletions in the
father and a single α-gene deletion in the patient. The cobalamin malabsorption is
likely due to a defect of the patient's intrinsic factor at the ilea! receptor sire. |
| format | Article |
| id | doaj-art-4cdd112fc6434fcb8b1d4178f1a4f182 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1989-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4cdd112fc6434fcb8b1d4178f1a4f1822025-02-03T05:52:21ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-0131343610.1155/1989/748604Cobalamin Malabsorption due to a Dysfunctional Intrinsic FactorJeanne Drouin0Nadia Mikhael1Departments of Medicine and Pathology, University of Ottawa, Ottawa General Hospital, Ottawa, Ontario, CanadaDepartments of Medicine and Pathology, University of Ottawa, Ottawa General Hospital, Ottawa, Ontario, CanadaAn 18-year-old French Canadian student presenting with a severe normocytic anemia, had undetectable serum cobalamin but normal gastric acidity and no evidence of generalized malabsorption. The gastric juice contained a normal quantity of intrinsic factor. Serum anti-intrinsic factor blocking antibodies were not present. Absorption of radiolabelled cobalamin given orally in the Schilling test was decreased but this was corrected by using hog intrinsic factor. Patient gastric juice bound cobalamin normally but did not promote uptake of this vitamin by homogenates of guinea pig intestinal mucosa. A family study showed normal cobalamin absorption for all tested subjects, as well as two α-hemoglobin gene deletions in the father and a single α-gene deletion in the patient. The cobalamin malabsorption is likely due to a defect of the patient's intrinsic factor at the ilea! receptor sire.http://dx.doi.org/10.1155/1989/748604 |
| spellingShingle | Jeanne Drouin Nadia Mikhael Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor Canadian Journal of Gastroenterology |
| title | Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor |
| title_full | Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor |
| title_fullStr | Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor |
| title_full_unstemmed | Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor |
| title_short | Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor |
| title_sort | cobalamin malabsorption due to a dysfunctional intrinsic factor |
| url | http://dx.doi.org/10.1155/1989/748604 |
| work_keys_str_mv | AT jeannedrouin cobalaminmalabsorptionduetoadysfunctionalintrinsicfactor AT nadiamikhael cobalaminmalabsorptionduetoadysfunctionalintrinsicfactor |