Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor
An 18-year-old French Canadian student presenting with a severe normocytic anemia, had undetectable serum cobalamin but normal gastric acidity and no evidence of generalized malabsorption. The gastric juice contained a normal quantity of intrinsic factor. Serum anti-intrinsic factor blocking antibod...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/748604 |
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| Summary: | An 18-year-old French Canadian student presenting with a severe
normocytic anemia, had undetectable serum cobalamin but normal gastric acidity
and no evidence of generalized malabsorption. The gastric juice contained a normal
quantity of intrinsic factor. Serum anti-intrinsic factor blocking antibodies were not
present. Absorption of radiolabelled cobalamin given orally in the Schilling test was
decreased but this was corrected by using hog intrinsic factor. Patient gastric juice
bound cobalamin normally but did not promote uptake of this vitamin by homogenates
of guinea pig intestinal mucosa. A family study showed normal cobalamin
absorption for all tested subjects, as well as two α-hemoglobin gene deletions in the
father and a single α-gene deletion in the patient. The cobalamin malabsorption is
likely due to a defect of the patient's intrinsic factor at the ilea! receptor sire. |
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| ISSN: | 0835-7900 |