Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation
Vascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents. Researchers have been eagerly seeking alternative methods that circumvent t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/854846 |
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| author | Yur-Ren Kuo Chien-Chang Chen Shigeru Goto Pao-Yuan Lin Fu-Chan Wei Chao-Long Chen |
| author_facet | Yur-Ren Kuo Chien-Chang Chen Shigeru Goto Pao-Yuan Lin Fu-Chan Wei Chao-Long Chen |
| author_sort | Yur-Ren Kuo |
| collection | DOAJ |
| description | Vascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents. Researchers have been eagerly seeking alternative methods that circumvent the long-term use of immunosuppressants. Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-, INF-γ, etc.), and interactions with dendritic or antigen presenting cells. In this paper, we summarize the current understanding of immunomodulation achieved by MSC therapies and introduce a possible outline for future clinical applications in VCA. |
| format | Article |
| id | doaj-art-4ccdf602d75f442cbfcb3dedc574c2d7 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4ccdf602d75f442cbfcb3dedc574c2d72025-02-03T01:00:54ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/854846854846Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite AllotransplantationYur-Ren Kuo0Chien-Chang Chen1Shigeru Goto2Pao-Yuan Lin3Fu-Chan Wei4Chao-Long Chen5Center for Vascularized Composite Allotransplantation, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanCenter for Vascularized Composite Allotransplantation, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanLiver Transplantation Program and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanCenter for Vascularized Composite Allotransplantation, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanCenter for Vascularized Composite Allotransplantation, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanLiver Transplantation Program and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanVascularized composite allotransplantations (VCAs) are not routinely performed for tissue reconstruction because of the potentially harmful adverse effects associated with lifelong administration of immunosuppressive agents. Researchers have been eagerly seeking alternative methods that circumvent the long-term use of immunosuppressants. Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-, INF-γ, etc.), and interactions with dendritic or antigen presenting cells. In this paper, we summarize the current understanding of immunomodulation achieved by MSC therapies and introduce a possible outline for future clinical applications in VCA.http://dx.doi.org/10.1155/2012/854846 |
| spellingShingle | Yur-Ren Kuo Chien-Chang Chen Shigeru Goto Pao-Yuan Lin Fu-Chan Wei Chao-Long Chen Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation Clinical and Developmental Immunology |
| title | Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation |
| title_full | Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation |
| title_fullStr | Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation |
| title_full_unstemmed | Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation |
| title_short | Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation |
| title_sort | mesenchymal stem cells as immunomodulators in a vascularized composite allotransplantation |
| url | http://dx.doi.org/10.1155/2012/854846 |
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