Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring
Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therap...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/690613 |
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| author | Jim Bush Karen So Tracey Mason Nick L. Occleston Sharon O'Kane Mark W. J. Ferguson |
| author_facet | Jim Bush Karen So Tracey Mason Nick L. Occleston Sharon O'Kane Mark W. J. Ferguson |
| author_sort | Jim Bush |
| collection | DOAJ |
| description | Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy. A wide range of non-invasive and invasive techniques have been used in an attempt to improve scarring although robust, prospective clinical trials to support the efficacy of these therapies are lacking. Differences in wound healing and scar outcome between early fetal and adult wounds led to interest in the role of the TGFβ family of cytokines in scar formation and the identification of TGFβ3 (avotermin) as a potential therapeutic agent for the improvement of scar appearance. Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin. Avotermin is safe and well tolerated and is currently in Phase III of clinical development, with the first study, in patients undergoing scar revision surgery, fully recruited. |
| format | Article |
| id | doaj-art-4cbdcaf9cfd84c6583cd3179b266d53f |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-4cbdcaf9cfd84c6583cd3179b266d53f2025-02-03T01:03:14ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/690613690613Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of ScarringJim Bush0Karen So1Tracey Mason2Nick L. Occleston3Sharon O'Kane4Mark W. J. Ferguson5Renovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKRenovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKRenovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKRenovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKRenovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKRenovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UKMany patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy. A wide range of non-invasive and invasive techniques have been used in an attempt to improve scarring although robust, prospective clinical trials to support the efficacy of these therapies are lacking. Differences in wound healing and scar outcome between early fetal and adult wounds led to interest in the role of the TGFβ family of cytokines in scar formation and the identification of TGFβ3 (avotermin) as a potential therapeutic agent for the improvement of scar appearance. Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin. Avotermin is safe and well tolerated and is currently in Phase III of clinical development, with the first study, in patients undergoing scar revision surgery, fully recruited.http://dx.doi.org/10.1155/2010/690613 |
| spellingShingle | Jim Bush Karen So Tracey Mason Nick L. Occleston Sharon O'Kane Mark W. J. Ferguson Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring Dermatology Research and Practice |
| title | Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring |
| title_full | Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring |
| title_fullStr | Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring |
| title_full_unstemmed | Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring |
| title_short | Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring |
| title_sort | therapies with emerging evidence of efficacy avotermin for the improvement of scarring |
| url | http://dx.doi.org/10.1155/2010/690613 |
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