Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare inflammatory condition that mostly affects lungs in smokers. On imaging, it usually presents as multiple, upper lobe predominant, solid, and cavitary nodules, but presentation as solitary pulmonary nodule (SPN) is rare. We describe a case of S...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2020/8872111 |
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| author | Hassan Baig Sushilkumar Sonavane Ian Makey Jorge Mallea Andras Khoor |
| author_facet | Hassan Baig Sushilkumar Sonavane Ian Makey Jorge Mallea Andras Khoor |
| author_sort | Hassan Baig |
| collection | DOAJ |
| description | Pulmonary Langerhans cell histiocytosis (PLCH) is a rare inflammatory condition that mostly affects lungs in smokers. On imaging, it usually presents as multiple, upper lobe predominant, solid, and cavitary nodules, but presentation as solitary pulmonary nodule (SPN) is rare. We describe a case of SPN seen on low-dose lung cancer screening CT (LDCT) that was FDG avid on PET/CT. Given concern for malignancy, lobectomy was planned if intraoperative frozen section was consistent with malignancy. Lobectomy was performed based on frozen section; however, on formal pathology review, the nodule was ultimately found to be PLCH. This case illustrates an atypical presentation of PLCH as a solitary nodule. Furthermore, it helps demonstrate how rare etiologies (like PLCH) may be more frequently encountered and should be considered in the differential diagnosis for solitary lung nodules, especially in the era of lung cancer screening. |
| format | Article |
| id | doaj-art-4cbc1108abcf4a95b1cd08820d9f260b |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-4cbc1108abcf4a95b1cd08820d9f260b2025-02-03T06:43:31ZengWileyCase Reports in Pulmonology2090-68462090-68542020-01-01202010.1155/2020/88721118872111Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CTHassan Baig0Sushilkumar Sonavane1Ian Makey2Jorge Mallea3Andras Khoor4Department of Pulmonary and Critical Care Medicine, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Diagnostic Radiology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Thoracic Surgery, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Pulmonary and Critical Care Medicine, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USADepartment of Anatomic and Clinical Pathology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USAPulmonary Langerhans cell histiocytosis (PLCH) is a rare inflammatory condition that mostly affects lungs in smokers. On imaging, it usually presents as multiple, upper lobe predominant, solid, and cavitary nodules, but presentation as solitary pulmonary nodule (SPN) is rare. We describe a case of SPN seen on low-dose lung cancer screening CT (LDCT) that was FDG avid on PET/CT. Given concern for malignancy, lobectomy was planned if intraoperative frozen section was consistent with malignancy. Lobectomy was performed based on frozen section; however, on formal pathology review, the nodule was ultimately found to be PLCH. This case illustrates an atypical presentation of PLCH as a solitary nodule. Furthermore, it helps demonstrate how rare etiologies (like PLCH) may be more frequently encountered and should be considered in the differential diagnosis for solitary lung nodules, especially in the era of lung cancer screening.http://dx.doi.org/10.1155/2020/8872111 |
| spellingShingle | Hassan Baig Sushilkumar Sonavane Ian Makey Jorge Mallea Andras Khoor Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT Case Reports in Pulmonology |
| title | Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT |
| title_full | Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT |
| title_fullStr | Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT |
| title_full_unstemmed | Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT |
| title_short | Pulmonary Langerhans Cell Histiocytosis Presenting as a Solitary Pulmonary Nodule on a Lung Cancer Screening CT |
| title_sort | pulmonary langerhans cell histiocytosis presenting as a solitary pulmonary nodule on a lung cancer screening ct |
| url | http://dx.doi.org/10.1155/2020/8872111 |
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