Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients
Purpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8506072 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567368381890560 |
|---|---|
| author | Ksenija Stach Susanne Karb Ibrahim Akin Martin Borggrefe Bernhard Krämer Thorsten Kälsch Anna-Isabelle Kälsch |
| author_facet | Ksenija Stach Susanne Karb Ibrahim Akin Martin Borggrefe Bernhard Krämer Thorsten Kälsch Anna-Isabelle Kälsch |
| author_sort | Ksenija Stach |
| collection | DOAJ |
| description | Purpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients. Methods. For this prospective comparative study, HD patients (n=41) and PD patients (n=10) were included. In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analysed by enzyme-linked immunosorbent assay. Results. Haemodialysis patients showed a significantly higher CD62P expression on platelets (p=0.017), significantly higher amount of platelet-monocyte aggregates (p<0.0001), and significantly more tissue factor binding on monocytes (p<0.0001) compared to PD patients. In PD patients, a significant correlation between Kt/V and platelet CD40L expression (r=0.867; 0.001) and between Kt/V and platelet CD62P expression (r=0.686; p=0.028) was observed, while there was no significant correlation between Kt/V and tissue factor binding on monocytes and platelet-monocyte aggregates, respectively. Conclusion. Platelet and monocyte activity markers are higher in HD patients in comparison with those in PD patients, possibly suggesting a higher risk of cardiovascular morbidity and mortality. |
| format | Article |
| id | doaj-art-4ca15ca9fc6b453a90a69e94d3328e96 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4ca15ca9fc6b453a90a69e94d3328e962025-02-03T01:01:36ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/85060728506072Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis PatientsKsenija Stach0Susanne Karb1Ibrahim Akin2Martin Borggrefe3Bernhard Krämer4Thorsten Kälsch5Anna-Isabelle Kälsch61st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany1st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany1st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany1st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany5th Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany1st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany5th Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GermanyPurpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients. Methods. For this prospective comparative study, HD patients (n=41) and PD patients (n=10) were included. In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analysed by enzyme-linked immunosorbent assay. Results. Haemodialysis patients showed a significantly higher CD62P expression on platelets (p=0.017), significantly higher amount of platelet-monocyte aggregates (p<0.0001), and significantly more tissue factor binding on monocytes (p<0.0001) compared to PD patients. In PD patients, a significant correlation between Kt/V and platelet CD40L expression (r=0.867; 0.001) and between Kt/V and platelet CD62P expression (r=0.686; p=0.028) was observed, while there was no significant correlation between Kt/V and tissue factor binding on monocytes and platelet-monocyte aggregates, respectively. Conclusion. Platelet and monocyte activity markers are higher in HD patients in comparison with those in PD patients, possibly suggesting a higher risk of cardiovascular morbidity and mortality.http://dx.doi.org/10.1155/2017/8506072 |
| spellingShingle | Ksenija Stach Susanne Karb Ibrahim Akin Martin Borggrefe Bernhard Krämer Thorsten Kälsch Anna-Isabelle Kälsch Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients Mediators of Inflammation |
| title | Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients |
| title_full | Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients |
| title_fullStr | Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients |
| title_full_unstemmed | Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients |
| title_short | Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients |
| title_sort | elevation of platelet and monocyte activity markers of atherosclerosis in haemodialysis patients compared to peritoneal dialysis patients |
| url | http://dx.doi.org/10.1155/2017/8506072 |
| work_keys_str_mv | AT ksenijastach elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT susannekarb elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT ibrahimakin elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT martinborggrefe elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT bernhardkramer elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT thorstenkalsch elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients AT annaisabellekalsch elevationofplateletandmonocyteactivitymarkersofatherosclerosisinhaemodialysispatientscomparedtoperitonealdialysispatients |