Disease burden of influenza in Spain: A five-season study (2015–2020)
Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospit...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2440206 |
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| author | Iván Sanz-Muñoz Irene Arroyo-Hernantes Alejandro Martín-Toribio Marina Toquero-Asensio Javier Sánchez-Martínez Carla Rodríguez-Crespo Silvia Rojo-Rello Marta Domínguez-Gil Marta Hernández-Pérez Eduardo Tamayo Ruth Gil-Prieto Ángel Gil-de-Miguel José M Eiros |
| author_facet | Iván Sanz-Muñoz Irene Arroyo-Hernantes Alejandro Martín-Toribio Marina Toquero-Asensio Javier Sánchez-Martínez Carla Rodríguez-Crespo Silvia Rojo-Rello Marta Domínguez-Gil Marta Hernández-Pérez Eduardo Tamayo Ruth Gil-Prieto Ángel Gil-de-Miguel José M Eiros |
| author_sort | Iván Sanz-Muñoz |
| collection | DOAJ |
| description | Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015–2020) via publicly available Minimum Basic Datasets (MDBS). The data revealed that influenza had a major impact in Spain, with approximately 29,000 hospitalizations, 2,200 ICU admissions, and 1,600 deaths each season. In this period, approximately 7.8% of those hospitalized required ICU admission, and 5.7% died in the hospital due to influenza, with wide differences in these parameters depending on the season due to the virological characteristics of the major circulating viruses. More than 60% of those hospitalized were over 65 years of age, and approximately 82% of those who died were elderly, demonstrating that the greatest burden of hospitalization and mortality is centered on this age group. The annual direct cost of influenza was approximately €128 million per season, with more than 80% of this cost centered on people over 45 years of age. |
| format | Article |
| id | doaj-art-4c9e33219c414fc6b42ede844a3a13fd |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-4c9e33219c414fc6b42ede844a3a13fd2025-01-27T22:26:58ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2024.2440206Disease burden of influenza in Spain: A five-season study (2015–2020)Iván Sanz-Muñoz0Irene Arroyo-Hernantes1Alejandro Martín-Toribio2Marina Toquero-Asensio3Javier Sánchez-Martínez4Carla Rodríguez-Crespo5Silvia Rojo-Rello6Marta Domínguez-Gil7Marta Hernández-Pérez8Eduardo Tamayo9Ruth Gil-Prieto10Ángel Gil-de-Miguel11José M Eiros12National Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainHospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainDepartment of Microbiology, Faculty of Medicine, Universidad de Valladolid, Valladolid, SpainDepartamento de Especialidades Médicas y Salud Pública, URJC, Madrid, SpainDepartamento de Especialidades Médicas y Salud Pública, URJC, Madrid, SpainNational Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, SpainInfluenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015–2020) via publicly available Minimum Basic Datasets (MDBS). The data revealed that influenza had a major impact in Spain, with approximately 29,000 hospitalizations, 2,200 ICU admissions, and 1,600 deaths each season. In this period, approximately 7.8% of those hospitalized required ICU admission, and 5.7% died in the hospital due to influenza, with wide differences in these parameters depending on the season due to the virological characteristics of the major circulating viruses. More than 60% of those hospitalized were over 65 years of age, and approximately 82% of those who died were elderly, demonstrating that the greatest burden of hospitalization and mortality is centered on this age group. The annual direct cost of influenza was approximately €128 million per season, with more than 80% of this cost centered on people over 45 years of age.https://www.tandfonline.com/doi/10.1080/21645515.2024.2440206Influenzaburden of diseasein-hospital mortalitylength of stayeconomic burden |
| spellingShingle | Iván Sanz-Muñoz Irene Arroyo-Hernantes Alejandro Martín-Toribio Marina Toquero-Asensio Javier Sánchez-Martínez Carla Rodríguez-Crespo Silvia Rojo-Rello Marta Domínguez-Gil Marta Hernández-Pérez Eduardo Tamayo Ruth Gil-Prieto Ángel Gil-de-Miguel José M Eiros Disease burden of influenza in Spain: A five-season study (2015–2020) Human Vaccines & Immunotherapeutics Influenza burden of disease in-hospital mortality length of stay economic burden |
| title | Disease burden of influenza in Spain: A five-season study (2015–2020) |
| title_full | Disease burden of influenza in Spain: A five-season study (2015–2020) |
| title_fullStr | Disease burden of influenza in Spain: A five-season study (2015–2020) |
| title_full_unstemmed | Disease burden of influenza in Spain: A five-season study (2015–2020) |
| title_short | Disease burden of influenza in Spain: A five-season study (2015–2020) |
| title_sort | disease burden of influenza in spain a five season study 2015 2020 |
| topic | Influenza burden of disease in-hospital mortality length of stay economic burden |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2440206 |
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