Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia
ABSTRACT Background and Aims Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale. Escherichia coli (E. coli) is a gram‐negative rod responsible for most UTI cases. ESBL‐producing E. coli is widely recognized as a sign...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583155464273920 |
|---|---|
| author | Khalid M. Alameer Bandar M. Abuageelah Rena H. Alharbi Mona H. Alfaifi Eman Hurissi Moayad Haddad Nabil Dhayhi Abdulelah S. Jafar Mousa Mobarki Hassan Awashi Shaqraa Musawi Abdulaziz M. Alameer Shatha H. Kariri Abdulaziz H. Alhazmi |
| author_facet | Khalid M. Alameer Bandar M. Abuageelah Rena H. Alharbi Mona H. Alfaifi Eman Hurissi Moayad Haddad Nabil Dhayhi Abdulelah S. Jafar Mousa Mobarki Hassan Awashi Shaqraa Musawi Abdulaziz M. Alameer Shatha H. Kariri Abdulaziz H. Alhazmi |
| author_sort | Khalid M. Alameer |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale. Escherichia coli (E. coli) is a gram‐negative rod responsible for most UTI cases. ESBL‐producing E. coli is widely recognized as a significant contributor to antibiotic resistance. This study aims to evaluate the prevalence and antibiotic resistance trends of ESBL‐producing E. coli in patients with UTIs at a tertiary hospital in Jazan, Saudi Arabia. Methods A retrospective cross‐sectional analysis was conducted on 347 urine specimens collected between January 2022 and March 2023. Results The study found that 31% of E. coli specimens were positive for ESBL. Among patients with ESBL‐producing E. coli, 78.9% were females, and the majority of ESBL‐producing E. coli cases were observed in the outpatient clinic departments. Among all E. coli isolates, ampicillin exhibited the highest resistance rate at 69.3%, aztreonam at 66.7%, and colistin at the lowest resistance. ESBL‐producing E. coli strains exhibited higher resistance rates than non‐ESBL‐producing E. coli strains. Conclusion The study agrees with others in the region and shows a higher prevalence of ESBL‐producing E. coli in the region, emphasizing the importance of antibiotic stewardship programs and infection control measures to mitigate the prevalence and spread of ESBL‐producing E. coli in our region. |
| format | Article |
| id | doaj-art-4c9481fd298c44f2b10a8cb08ff28271 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-4c9481fd298c44f2b10a8cb08ff282712025-01-29T03:42:39ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70378Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi ArabiaKhalid M. Alameer0Bandar M. Abuageelah1Rena H. Alharbi2Mona H. Alfaifi3Eman Hurissi4Moayad Haddad5Nabil Dhayhi6Abdulelah S. Jafar7Mousa Mobarki8Hassan Awashi9Shaqraa Musawi10Abdulaziz M. Alameer11Shatha H. Kariri12Abdulaziz H. Alhazmi13Faculty of Medicine Jazan University Jazan Saudi ArabiaGeneral Medicine Practice Program Batterjee Medical College Abha Saudi ArabiaFaculty of Medicine Jazan University Jazan Saudi ArabiaGeneral Medicine Practice Program Batterjee Medical College Abha Saudi ArabiaOphthalmology Division, Department of Surgery Prince Mohammed Bin Naser Hospital Jazan Saudi ArabiaDepartment of Pediatric Infectious Diseases King Fahad Central Hospital Jazan Saudi ArabiaDepartment of Pediatric Infectious Diseases King Fahad Central Hospital Jazan Saudi ArabiaDepartment of Pediatric Infectious Diseases King Fahad Central Hospital Jazan Saudi ArabiaFaculty of Medicine Jazan University Jazan Saudi ArabiaJazan Regional Laboratory, Ministry of Health Jazan Saudi ArabiaFaculty of Medical Applied Science Jazan University Jazan Saudi ArabiaFaculty of Medical Applied Science Jazan University Jazan Saudi ArabiaFaculty of Medicine Jazan University Jazan Saudi ArabiaFaculty of Medicine Jazan University Jazan Saudi ArabiaABSTRACT Background and Aims Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale. Escherichia coli (E. coli) is a gram‐negative rod responsible for most UTI cases. ESBL‐producing E. coli is widely recognized as a significant contributor to antibiotic resistance. This study aims to evaluate the prevalence and antibiotic resistance trends of ESBL‐producing E. coli in patients with UTIs at a tertiary hospital in Jazan, Saudi Arabia. Methods A retrospective cross‐sectional analysis was conducted on 347 urine specimens collected between January 2022 and March 2023. Results The study found that 31% of E. coli specimens were positive for ESBL. Among patients with ESBL‐producing E. coli, 78.9% were females, and the majority of ESBL‐producing E. coli cases were observed in the outpatient clinic departments. Among all E. coli isolates, ampicillin exhibited the highest resistance rate at 69.3%, aztreonam at 66.7%, and colistin at the lowest resistance. ESBL‐producing E. coli strains exhibited higher resistance rates than non‐ESBL‐producing E. coli strains. Conclusion The study agrees with others in the region and shows a higher prevalence of ESBL‐producing E. coli in the region, emphasizing the importance of antibiotic stewardship programs and infection control measures to mitigate the prevalence and spread of ESBL‐producing E. coli in our region.https://doi.org/10.1002/hsr2.70378antibiotic resistanceextended‐spectrum β‐lactamases (ESBLs)JazanSaudi Arabiaurinary tract infections (UTIs)uropathogenic E. coli (UPEC) |
| spellingShingle | Khalid M. Alameer Bandar M. Abuageelah Rena H. Alharbi Mona H. Alfaifi Eman Hurissi Moayad Haddad Nabil Dhayhi Abdulelah S. Jafar Mousa Mobarki Hassan Awashi Shaqraa Musawi Abdulaziz M. Alameer Shatha H. Kariri Abdulaziz H. Alhazmi Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia Health Science Reports antibiotic resistance extended‐spectrum β‐lactamases (ESBLs) Jazan Saudi Arabia urinary tract infections (UTIs) uropathogenic E. coli (UPEC) |
| title | Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia |
| title_full | Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia |
| title_fullStr | Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia |
| title_full_unstemmed | Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia |
| title_short | Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic Escherichia coli With Focus on Extended‐Spectrum β‐Lactamase at a Tertiary Central Hospital in Saudi Arabia |
| title_sort | retrospective analysis of antibiotic resistance patterns of uropathogenic escherichia coli with focus on extended spectrum β lactamase at a tertiary central hospital in saudi arabia |
| topic | antibiotic resistance extended‐spectrum β‐lactamases (ESBLs) Jazan Saudi Arabia urinary tract infections (UTIs) uropathogenic E. coli (UPEC) |
| url | https://doi.org/10.1002/hsr2.70378 |
| work_keys_str_mv | AT khalidmalameer retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT bandarmabuageelah retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT renahalharbi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT monahalfaifi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT emanhurissi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT moayadhaddad retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT nabildhayhi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT abdulelahsjafar retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT mousamobarki retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT hassanawashi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT shaqraamusawi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT abdulazizmalameer retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT shathahkariri retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia AT abdulazizhalhazmi retrospectiveanalysisofantibioticresistancepatternsofuropathogenicescherichiacoliwithfocusonextendedspectrumblactamaseatatertiarycentralhospitalinsaudiarabia |