Building microbial communities to improve antimicrobial strategies
Abstract The lack of novel antimicrobial compounds in the development pipeline cries for innovative approaches regarding their discovery. In this Perspective, we discuss how microbial interactions play a significant role in shifting a pathogen’s response to antibacterial treatment and negatively imp...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00115-1 |
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| _version_ | 1850231348147519488 |
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| author | Laurence Couture Fabrice Jean-Pierre Jean-Philippe Côté |
| author_facet | Laurence Couture Fabrice Jean-Pierre Jean-Philippe Côté |
| author_sort | Laurence Couture |
| collection | DOAJ |
| description | Abstract The lack of novel antimicrobial compounds in the development pipeline cries for innovative approaches regarding their discovery. In this Perspective, we discuss how microbial interactions play a significant role in shifting a pathogen’s response to antibacterial treatment and negatively impact patient outcomes. Furthermore, we argue that interspecies interactions are often overlooked in treatment selection and current drug screening approaches, and modeling disease-relevant polymicrobial communities could help in unraveling novel strategies to eradicate pathogens. |
| format | Article |
| id | doaj-art-4c8bd5faa7da4bd0b56bb6bc8cb1dba2 |
| institution | OA Journals |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-4c8bd5faa7da4bd0b56bb6bc8cb1dba22025-08-20T02:03:34ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-05-01311510.1038/s44259-025-00115-1Building microbial communities to improve antimicrobial strategiesLaurence Couture0Fabrice Jean-Pierre1Jean-Philippe Côté2Département de biologie, Université de Sherbrooke, SherbrookeDépartement de biologie, Université de Sherbrooke, SherbrookeDépartement de biologie, Université de Sherbrooke, SherbrookeAbstract The lack of novel antimicrobial compounds in the development pipeline cries for innovative approaches regarding their discovery. In this Perspective, we discuss how microbial interactions play a significant role in shifting a pathogen’s response to antibacterial treatment and negatively impact patient outcomes. Furthermore, we argue that interspecies interactions are often overlooked in treatment selection and current drug screening approaches, and modeling disease-relevant polymicrobial communities could help in unraveling novel strategies to eradicate pathogens.https://doi.org/10.1038/s44259-025-00115-1 |
| spellingShingle | Laurence Couture Fabrice Jean-Pierre Jean-Philippe Côté Building microbial communities to improve antimicrobial strategies npj Antimicrobials and Resistance |
| title | Building microbial communities to improve antimicrobial strategies |
| title_full | Building microbial communities to improve antimicrobial strategies |
| title_fullStr | Building microbial communities to improve antimicrobial strategies |
| title_full_unstemmed | Building microbial communities to improve antimicrobial strategies |
| title_short | Building microbial communities to improve antimicrobial strategies |
| title_sort | building microbial communities to improve antimicrobial strategies |
| url | https://doi.org/10.1038/s44259-025-00115-1 |
| work_keys_str_mv | AT laurencecouture buildingmicrobialcommunitiestoimproveantimicrobialstrategies AT fabricejeanpierre buildingmicrobialcommunitiestoimproveantimicrobialstrategies AT jeanphilippecote buildingmicrobialcommunitiestoimproveantimicrobialstrategies |