Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease
Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current findings on the relationship between ApoE and...
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| Format: | Article |
| Language: | zho |
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Editorial Office of International Journal of Geriatrics
2025-01-01
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| Series: | Guoji laonian yixue zazhi |
| Subjects: | |
| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.018&lang=en |
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| _version_ | 1832592783509028864 |
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| author | Jiayuan Li Ting Liu Shengxi Meng |
| author_facet | Jiayuan Li Ting Liu Shengxi Meng |
| author_sort | Jiayuan Li |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current findings on the relationship between ApoE and AD, the impact of APOE gene polymorphisms on AD, the interaction between ApoE and other pathogenic factors, and the role of ApoE in AD.Additionally, it discusses the diagnosis and treatment of AD to enhance the understanding of its pathogenesis and to provide new perspectives for the prevention and management of the disease. |
| format | Article |
| id | doaj-art-4c8951e078b147fbae692c1bff9267a1 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-4c8951e078b147fbae692c1bff9267a12025-01-21T02:59:39ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-01-01461919510.3969/j.issn.1674-7593.2025.01.018Research progress on the mechanisms of apolipoprotein E in Alzheimer’s diseaseJiayuan Li0Ting Liu1Shengxi Meng2Shanghai Jiao Tong University School of Medicine, Shanghai 200025Shanghai Jiao Tong University School of Medicine, Shanghai 200025Department of Chinese Internal Medicine, Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current findings on the relationship between ApoE and AD, the impact of APOE gene polymorphisms on AD, the interaction between ApoE and other pathogenic factors, and the role of ApoE in AD.Additionally, it discusses the diagnosis and treatment of AD to enhance the understanding of its pathogenesis and to provide new perspectives for the prevention and management of the disease.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.018&lang=enalzheimer’s diseaseapolipoprotein emechanism |
| spellingShingle | Jiayuan Li Ting Liu Shengxi Meng Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease Guoji laonian yixue zazhi alzheimer’s disease apolipoprotein e mechanism |
| title | Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease |
| title_full | Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease |
| title_fullStr | Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease |
| title_full_unstemmed | Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease |
| title_short | Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease |
| title_sort | research progress on the mechanisms of apolipoprotein e in alzheimer s disease |
| topic | alzheimer’s disease apolipoprotein e mechanism |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.018&lang=en |
| work_keys_str_mv | AT jiayuanli researchprogressonthemechanismsofapolipoproteineinalzheimersdisease AT tingliu researchprogressonthemechanismsofapolipoproteineinalzheimersdisease AT shengximeng researchprogressonthemechanismsofapolipoproteineinalzheimersdisease |