Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects

Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects

Drug development faces significant financial and time challenges, highlighting the need for more efficient strategies. This study evaluated the druggability of the entire human proteome using Fpocket. We identified 15,043 druggable pockets in 20,255 predicted protein structures, significantly expand...

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Bibliographic Details
Main Authors: Renxin Zhang, Zhiyuan Chen, Shuhan Li, Haohao Lv, Jinjun Li, Naixue Yang, Shaoxing Dai
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
druggability
proteome
drug repurposing
side effects prediction
drug–protein interactions
Online Access:https://www.mdpi.com/1420-3049/30/2/260
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