Metabolic control of ovarian function through the sympathetic nervous system: role of leptin
The link between metabolism and reproduction is well-known. Both undernutrition and obesity affect the reproductive system. Metabolic status influences reproductive physiology by regulating gonadotropin secretion and affecting reproductive organs through hormonal signals. On the other hand, the auto...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1484939/full |
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| author | Camila Astudillo-Guerrero Alfonso H. Paredes Jorge Escobar Daniela Fernandois Rafael Barra Gonzalo Cruz |
| author_facet | Camila Astudillo-Guerrero Alfonso H. Paredes Jorge Escobar Daniela Fernandois Rafael Barra Gonzalo Cruz |
| author_sort | Camila Astudillo-Guerrero |
| collection | DOAJ |
| description | The link between metabolism and reproduction is well-known. Both undernutrition and obesity affect the reproductive system. Metabolic status influences reproductive physiology by regulating gonadotropin secretion and affecting reproductive organs through hormonal signals. On the other hand, the autonomic nervous system controls follicle development and ovulation in the female reproductive system. This system is regulated by hypothalamic areas associated with metabolism as the Arcuate nuclei (ARC) and paraventricular nuclei (PVN). Metabolic signals, such as nutrients and hormones, acting on the hypothalamus may play a crucial role in modulating sympathetic innervation of the ovary and other reproductive organs. Some of these hormones are leptin, insulin, and GLP-1 that act directly in the hypothalamus to activate the sympathetic nervous system. In this minireview, we propose that leptin could be an important regulator of sympathetic innervation in reproductive tissues. Leptin may affect the density or activity of sympathetic nerves, thereby affecting reproductive function. We also speculate that other hormones such as insulin and GLP-1 may activate sympathetic nerves to the ovary. Additionally, we explore how early-onset obesity can cause lasting changes in the autonomic control of metabolic and reproductive organs, especially in the ovary. This suggests that the hyperactivation of sympathetic nerves in adulthood, due to metabolic programming, could be a possible cause of reproductive and metabolic disorders, such as polycystic ovary syndrome. |
| format | Article |
| id | doaj-art-4c8587b3c5864669aaa456b3eb7ec30b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-4c8587b3c5864669aaa456b3eb7ec30b2025-02-03T05:11:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011510.3389/fendo.2024.14849391484939Metabolic control of ovarian function through the sympathetic nervous system: role of leptinCamila Astudillo-Guerrero0Alfonso H. Paredes1Jorge Escobar2Daniela Fernandois3Rafael Barra4Gonzalo Cruz5Laboratorio de Alteraciones Reproductivas y Metabólicas, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, ChileCenter for Neurobiochemical Studies in Endocrine Diseases, Laboratory of Neurobiochemistry, Department of Biochemistry and Molecular Biology, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, ChileLaboratorio de Química Biológica, Instituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso, ChileUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, Lille, FranceCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, ChileLaboratorio de Alteraciones Reproductivas y Metabólicas, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, ChileThe link between metabolism and reproduction is well-known. Both undernutrition and obesity affect the reproductive system. Metabolic status influences reproductive physiology by regulating gonadotropin secretion and affecting reproductive organs through hormonal signals. On the other hand, the autonomic nervous system controls follicle development and ovulation in the female reproductive system. This system is regulated by hypothalamic areas associated with metabolism as the Arcuate nuclei (ARC) and paraventricular nuclei (PVN). Metabolic signals, such as nutrients and hormones, acting on the hypothalamus may play a crucial role in modulating sympathetic innervation of the ovary and other reproductive organs. Some of these hormones are leptin, insulin, and GLP-1 that act directly in the hypothalamus to activate the sympathetic nervous system. In this minireview, we propose that leptin could be an important regulator of sympathetic innervation in reproductive tissues. Leptin may affect the density or activity of sympathetic nerves, thereby affecting reproductive function. We also speculate that other hormones such as insulin and GLP-1 may activate sympathetic nerves to the ovary. Additionally, we explore how early-onset obesity can cause lasting changes in the autonomic control of metabolic and reproductive organs, especially in the ovary. This suggests that the hyperactivation of sympathetic nerves in adulthood, due to metabolic programming, could be a possible cause of reproductive and metabolic disorders, such as polycystic ovary syndrome.https://www.frontiersin.org/articles/10.3389/fendo.2024.1484939/fullsympatheticovaryleptinhypothalamusmetabolic |
| spellingShingle | Camila Astudillo-Guerrero Alfonso H. Paredes Jorge Escobar Daniela Fernandois Rafael Barra Gonzalo Cruz Metabolic control of ovarian function through the sympathetic nervous system: role of leptin Frontiers in Endocrinology sympathetic ovary leptin hypothalamus metabolic |
| title | Metabolic control of ovarian function through the sympathetic nervous system: role of leptin |
| title_full | Metabolic control of ovarian function through the sympathetic nervous system: role of leptin |
| title_fullStr | Metabolic control of ovarian function through the sympathetic nervous system: role of leptin |
| title_full_unstemmed | Metabolic control of ovarian function through the sympathetic nervous system: role of leptin |
| title_short | Metabolic control of ovarian function through the sympathetic nervous system: role of leptin |
| title_sort | metabolic control of ovarian function through the sympathetic nervous system role of leptin |
| topic | sympathetic ovary leptin hypothalamus metabolic |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1484939/full |
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