Leukocyte Telomere Length and Cognitive Function in Older Adults
We evaluated the specific association between leukocyte telomere length and cognitive function among a national sample of the broader U.S. older adult population. Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 1,722 adults, between 60-85 years...
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| Format: | Article |
| Language: | English |
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Kare Publishing
2018-04-01
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| Series: | Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=273242 |
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| author | Emily Frith Paul D. Loprinzi |
| author_facet | Emily Frith Paul D. Loprinzi |
| author_sort | Emily Frith |
| collection | DOAJ |
| description | We evaluated the specific association between leukocyte telomere length and cognitive function among a national sample of the broader U.S. older adult population. Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 1,722 adults, between 60-85 years, with complete data on selected study variables. DNA was extracted from whole blood via the LTL assay, which is administered using quantitative polymerase chain reaction to measure telomere length relative to standard reference DNA (T/S ratio). Average telomere length was recorded, with two to three assays performed to control for individual variability. The DSST (Digit Symbol Substitution Test) was used to assess participant executive cognitive functioning tasks of pairing and free recall. Individuals were excluded if they had been diagnosed with coronary artery disease, congestive heart failure, heart attack or stroke at the baseline assessment. Leukocyte telomere length was associated with higher cognitive performance, independent of gender, race-ethnicity, physical activity status, body mass index and other covariates. In this sample, there was a strong association between LTL and cognition; for every 1 T/S ratio increase in LTL, there was a corresponding 9.9 unit increase in the DSST (β = 9.9; 95% CI: 5.6-14.2; P [JCBPR 2018; 7(1.000): 14-18] |
| format | Article |
| id | doaj-art-4c75e16008a9462f86d0ed1e99e6c905 |
| institution | Kabale University |
| issn | 2146-9490 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | Kare Publishing |
| record_format | Article |
| series | Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi |
| spelling | doaj-art-4c75e16008a9462f86d0ed1e99e6c9052025-02-03T10:15:45ZengKare PublishingBilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi2146-94902018-04-0171141810.5455/JCBPR.273242273242Leukocyte Telomere Length and Cognitive Function in Older AdultsEmily Frith0Paul D. Loprinzi1University of Mississippi University of MississippiWe evaluated the specific association between leukocyte telomere length and cognitive function among a national sample of the broader U.S. older adult population. Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 1,722 adults, between 60-85 years, with complete data on selected study variables. DNA was extracted from whole blood via the LTL assay, which is administered using quantitative polymerase chain reaction to measure telomere length relative to standard reference DNA (T/S ratio). Average telomere length was recorded, with two to three assays performed to control for individual variability. The DSST (Digit Symbol Substitution Test) was used to assess participant executive cognitive functioning tasks of pairing and free recall. Individuals were excluded if they had been diagnosed with coronary artery disease, congestive heart failure, heart attack or stroke at the baseline assessment. Leukocyte telomere length was associated with higher cognitive performance, independent of gender, race-ethnicity, physical activity status, body mass index and other covariates. In this sample, there was a strong association between LTL and cognition; for every 1 T/S ratio increase in LTL, there was a corresponding 9.9 unit increase in the DSST (β = 9.9; 95% CI: 5.6-14.2; P [JCBPR 2018; 7(1.000): 14-18]http://www.ejmanager.com/fulltextpdf.php?mno=273242Epidemiology; health promotion; immune function; mental health; physical activity |
| spellingShingle | Emily Frith Paul D. Loprinzi Leukocyte Telomere Length and Cognitive Function in Older Adults Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi Epidemiology; health promotion; immune function; mental health; physical activity |
| title | Leukocyte Telomere Length and Cognitive Function in Older Adults |
| title_full | Leukocyte Telomere Length and Cognitive Function in Older Adults |
| title_fullStr | Leukocyte Telomere Length and Cognitive Function in Older Adults |
| title_full_unstemmed | Leukocyte Telomere Length and Cognitive Function in Older Adults |
| title_short | Leukocyte Telomere Length and Cognitive Function in Older Adults |
| title_sort | leukocyte telomere length and cognitive function in older adults |
| topic | Epidemiology; health promotion; immune function; mental health; physical activity |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=273242 |
| work_keys_str_mv | AT emilyfrith leukocytetelomerelengthandcognitivefunctioninolderadults AT pauldloprinzi leukocytetelomerelengthandcognitivefunctioninolderadults |