Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients
Background The assessment of left ventricular (LV) remodeling and its association with mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been systematically studied. We aimed to evaluate LV remodeling changes one year after kidney transplantation (KT) and identify their...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300303 |
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| _version_ | 1832591092723220480 |
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| author | Li Sun Dongliang Zhang Jiawen Liu Xiang Gao Chuanjian Suo Shuang Fei Zhengkai Huang Zijie Wang Hao Chen Jun Tao Zhijian Han Xiaobing Ju Zengjun Wang Min Gu Ruoyun Tan |
| author_facet | Li Sun Dongliang Zhang Jiawen Liu Xiang Gao Chuanjian Suo Shuang Fei Zhengkai Huang Zijie Wang Hao Chen Jun Tao Zhijian Han Xiaobing Ju Zengjun Wang Min Gu Ruoyun Tan |
| author_sort | Li Sun |
| collection | DOAJ |
| description | Background The assessment of left ventricular (LV) remodeling and its association with mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been systematically studied. We aimed to evaluate LV remodeling changes one year after kidney transplantation (KT) and identify their influencing factors.Methods Ninety-five KTRs (68 males; ages 40.2 ± 10.8 years) were followed before and one year after KT. Traditional risk factors and bone metabolism indicators were assessed. Left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF) and left ventricular diastolic dysfunction (LVDD) were measured using two-dimensional transthoracic echocardiography. The relationship between MBD and LV remodeling and the factors influencing LV remodeling were analyzed.Results One year after KT, MBD was partially improved, mainly characterized by hypercalcemia, hypophosphatemia, hyperparathyroidism, 25-(OH) vitamin D deficiency, elevated bone turnover markers, and bone loss. LVMI, the prevalence of left ventricular hypertrophy (LVH), and the prevalence of LVDD decreased, while LVEF increased. LVH was positively associated with postoperative intact parathyroid hormone (iPTH) and iPTH nonnormalization. ΔLVMI was positively associated with preoperative type-I collagen N-terminal peptide and postoperative iPTH. LVEF was negatively associated with postoperative phosphorous. ΔLVEF was negatively associated with postoperative iPTH. LVDD was positively associated with postoperative lumbar spine osteoporosis. Preoperative LVMI was negatively associated with ΔLVMI and positively associated with ΔLVEF. Advanced age, increased BMI, diabetes, longer dialysis time, lower albumin level, and higher total cholesterol and low-density lipoprotein levels were associated with LV remodeling.Conclusions LV remodeling partially improved after KT, showing a close relationship with MBD. |
| format | Article |
| id | doaj-art-4c6b661cb1684d37ad9bd55dbcc55d5b |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-4c6b661cb1684d37ad9bd55dbcc55d5b2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2300303Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipientsLi Sun0Dongliang Zhang1Jiawen Liu2Xiang Gao3Chuanjian Suo4Shuang Fei5Zhengkai Huang6Zijie Wang7Hao Chen8Jun Tao9Zhijian Han10Xiaobing Ju11Zengjun Wang12Min Gu13Ruoyun Tan14Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBackground The assessment of left ventricular (LV) remodeling and its association with mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been systematically studied. We aimed to evaluate LV remodeling changes one year after kidney transplantation (KT) and identify their influencing factors.Methods Ninety-five KTRs (68 males; ages 40.2 ± 10.8 years) were followed before and one year after KT. Traditional risk factors and bone metabolism indicators were assessed. Left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF) and left ventricular diastolic dysfunction (LVDD) were measured using two-dimensional transthoracic echocardiography. The relationship between MBD and LV remodeling and the factors influencing LV remodeling were analyzed.Results One year after KT, MBD was partially improved, mainly characterized by hypercalcemia, hypophosphatemia, hyperparathyroidism, 25-(OH) vitamin D deficiency, elevated bone turnover markers, and bone loss. LVMI, the prevalence of left ventricular hypertrophy (LVH), and the prevalence of LVDD decreased, while LVEF increased. LVH was positively associated with postoperative intact parathyroid hormone (iPTH) and iPTH nonnormalization. ΔLVMI was positively associated with preoperative type-I collagen N-terminal peptide and postoperative iPTH. LVEF was negatively associated with postoperative phosphorous. ΔLVEF was negatively associated with postoperative iPTH. LVDD was positively associated with postoperative lumbar spine osteoporosis. Preoperative LVMI was negatively associated with ΔLVMI and positively associated with ΔLVEF. Advanced age, increased BMI, diabetes, longer dialysis time, lower albumin level, and higher total cholesterol and low-density lipoprotein levels were associated with LV remodeling.Conclusions LV remodeling partially improved after KT, showing a close relationship with MBD.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300303Kidney transplantationmineral and bone disorderleft ventricular remodelingleft ventricular hypertrophy |
| spellingShingle | Li Sun Dongliang Zhang Jiawen Liu Xiang Gao Chuanjian Suo Shuang Fei Zhengkai Huang Zijie Wang Hao Chen Jun Tao Zhijian Han Xiaobing Ju Zengjun Wang Min Gu Ruoyun Tan Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients Renal Failure Kidney transplantation mineral and bone disorder left ventricular remodeling left ventricular hypertrophy |
| title | Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| title_full | Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| title_fullStr | Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| title_full_unstemmed | Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| title_short | Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| title_sort | left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients |
| topic | Kidney transplantation mineral and bone disorder left ventricular remodeling left ventricular hypertrophy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2300303 |
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