Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia
Pneumococcal diseases, or infections from the etiological agent Streptococcus pneumoniae, have long been a major cause of morbidity andmortality worldwide. Recent advances in the development of vaccines for theseinfections have raised questions concerning their widespread and/or long-termuse. In thi...
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| Format: | Article |
| Language: | English |
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AIMS Press
2007-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2008.5.175 |
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| author | Karyn L. Sutton H.T. Banks Carlos Castillo-Chávez |
| author_facet | Karyn L. Sutton H.T. Banks Carlos Castillo-Chávez |
| author_sort | Karyn L. Sutton |
| collection | DOAJ |
| description | Pneumococcal diseases, or infections from the etiological agent Streptococcus pneumoniae, have long been a major cause of morbidity andmortality worldwide. Recent advances in the development of vaccines for theseinfections have raised questions concerning their widespread and/or long-termuse. In this work, we use surveillance data collected by the Australian NationalNotifiable Diseases Surveillance system to estimate parameters in a mathemat-ical model of pneumococcal infection dynamics in a population with partialvaccination. The parameters obtained are of particular interest as they are nottypically available in reported literature or measurable. The calibrated modelis then used to assess the impact of the recent federally funded program thatprovides pneumococcal vaccines to large risk groups. The results presentedhere suggest the state of these infections may be changing in response to theprograms, and warrants close quantitative monitoring. |
| format | Article |
| id | doaj-art-4c67ad3718b44127918b55c459cca5f9 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2007-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-4c67ad3718b44127918b55c459cca5f92025-01-24T01:57:50ZengAIMS PressMathematical Biosciences and Engineering1551-00182007-12-015117520410.3934/mbe.2008.5.175Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in AustraliaKaryn L. Sutton0H.T. Banks1Carlos Castillo-Chávez2Department of Mathematics & Statistics, Arizona State University, Tempe, AZ, 85287-1804Department of Mathematics & Statistics, Arizona State University, Tempe, AZ, 85287-1804Department of Mathematics & Statistics, Arizona State University, Tempe, AZ, 85287-1804Pneumococcal diseases, or infections from the etiological agent Streptococcus pneumoniae, have long been a major cause of morbidity andmortality worldwide. Recent advances in the development of vaccines for theseinfections have raised questions concerning their widespread and/or long-termuse. In this work, we use surveillance data collected by the Australian NationalNotifiable Diseases Surveillance system to estimate parameters in a mathemat-ical model of pneumococcal infection dynamics in a population with partialvaccination. The parameters obtained are of particular interest as they are nottypically available in reported literature or measurable. The calibrated modelis then used to assess the impact of the recent federally funded program thatprovides pneumococcal vaccines to large risk groups. The results presentedhere suggest the state of these infections may be changing in response to theprograms, and warrants close quantitative monitoring.https://www.aimspress.com/article/doi/10.3934/mbe.2008.5.175pneumococcal infectiondynamicsinverse prob- lemspopulation modelstatistical methods. |
| spellingShingle | Karyn L. Sutton H.T. Banks Carlos Castillo-Chávez Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia Mathematical Biosciences and Engineering pneumococcal infectiondynamics inverse prob- lems population model statistical methods. |
| title | Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia |
| title_full | Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia |
| title_fullStr | Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia |
| title_full_unstemmed | Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia |
| title_short | Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia |
| title_sort | estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in australia |
| topic | pneumococcal infectiondynamics inverse prob- lems population model statistical methods. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2008.5.175 |
| work_keys_str_mv | AT karynlsutton estimationofinvasivepneumococcaldiseasedynamicsparametersandtheimpactofconjugatevaccinationinaustralia AT htbanks estimationofinvasivepneumococcaldiseasedynamicsparametersandtheimpactofconjugatevaccinationinaustralia AT carloscastillochavez estimationofinvasivepneumococcaldiseasedynamicsparametersandtheimpactofconjugatevaccinationinaustralia |