Positive association between proinsulin and fatty liver index in people with type 2 diabetes
The post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 partici...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0403/_html/-char/en |
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| author | Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi |
| author_facet | Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi |
| author_sort | Akinobu Nakamura |
| collection | DOAJ |
| description | The post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index group than in the low or moderate groups (all p < 0.01). The moderate fatty liver index group showed higher logarithm-transformed proinsulin than the low group (both p < 0.01). Positive associations between proinsulin and fatty liver index shown in this study would support an involvement of hepato-pancreatic crosstalk in the pathophysiology of type 2 diabetes. |
| format | Article |
| id | doaj-art-4c60741ec65042deb777aa96c3cc05bf |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-4c60741ec65042deb777aa96c3cc05bf2025-01-22T06:33:21ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-02-0171219319710.1507/endocrj.EJ23-0403endocrjPositive association between proinsulin and fatty liver index in people with type 2 diabetesAkinobu Nakamura0Aika Miya1Yuka Suzuki2Hiroshi Nomoto3Hiraku Kameda4Kyu Yong Cho5So Nagai6Tatsuya Atsumi7Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDivision of Diabetes and Endocrinology, Department of Medicine, NTT Sapporo Medical Center, Sapporo 060-0061, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanThe post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index group than in the low or moderate groups (all p < 0.01). The moderate fatty liver index group showed higher logarithm-transformed proinsulin than the low group (both p < 0.01). Positive associations between proinsulin and fatty liver index shown in this study would support an involvement of hepato-pancreatic crosstalk in the pathophysiology of type 2 diabetes.https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0403/_html/-char/enfatty liver indexhepatic steatosisproinsulin |
| spellingShingle | Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi Positive association between proinsulin and fatty liver index in people with type 2 diabetes Endocrine Journal fatty liver index hepatic steatosis proinsulin |
| title | Positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| title_full | Positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| title_fullStr | Positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| title_full_unstemmed | Positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| title_short | Positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| title_sort | positive association between proinsulin and fatty liver index in people with type 2 diabetes |
| topic | fatty liver index hepatic steatosis proinsulin |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0403/_html/-char/en |
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