The Enteric Nervous System in Intestinal Inflammation
Since about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. Consideration is given to two possible...
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/502865 |
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| _version_ | 1832564953078300672 |
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| author | Keith A Sharkey Edward J Parr |
| author_facet | Keith A Sharkey Edward J Parr |
| author_sort | Keith A Sharkey |
| collection | DOAJ |
| description | Since about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. Consideration is given to two possible ways that nerves are involved in IBD. First, nerves may play a role in the development or maintenance of inflammation through local release of transmitters. Second, once initiated (by whatever means), the processes of inflammation may disrupt the normal pattern of innervation and the interactions of nerves and their target tissues. Many of the functional disturbances observed in IBD are likely due to an alteration in the enteric nervous system either structurally through disruptions of nerve-target relationships or by modifications of neurotransmitters or their receptors. Finally, it appears that the enteric nervous system may be a potential therapeutic target in IBD and that neuroactive drugs acting locally can represent useful agents in the management of this disease. |
| format | Article |
| id | doaj-art-4c45ae647d814e92bfc4947867494917 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4c45ae647d814e92bfc49478674949172025-02-03T01:09:45ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-0110533534110.1155/1996/502865The Enteric Nervous System in Intestinal InflammationKeith A Sharkey0Edward J Parr1Neuroscience and Gastrointestinal Research Groups, Department of Medical Physiology, The University of Calgary, Calgary, Alberta, CanadaNeuroscience and Gastrointestinal Research Groups, Department of Medical Physiology, The University of Calgary, Calgary, Alberta, CanadaSince about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. Consideration is given to two possible ways that nerves are involved in IBD. First, nerves may play a role in the development or maintenance of inflammation through local release of transmitters. Second, once initiated (by whatever means), the processes of inflammation may disrupt the normal pattern of innervation and the interactions of nerves and their target tissues. Many of the functional disturbances observed in IBD are likely due to an alteration in the enteric nervous system either structurally through disruptions of nerve-target relationships or by modifications of neurotransmitters or their receptors. Finally, it appears that the enteric nervous system may be a potential therapeutic target in IBD and that neuroactive drugs acting locally can represent useful agents in the management of this disease.http://dx.doi.org/10.1155/1996/502865 |
| spellingShingle | Keith A Sharkey Edward J Parr The Enteric Nervous System in Intestinal Inflammation Canadian Journal of Gastroenterology |
| title | The Enteric Nervous System in Intestinal Inflammation |
| title_full | The Enteric Nervous System in Intestinal Inflammation |
| title_fullStr | The Enteric Nervous System in Intestinal Inflammation |
| title_full_unstemmed | The Enteric Nervous System in Intestinal Inflammation |
| title_short | The Enteric Nervous System in Intestinal Inflammation |
| title_sort | enteric nervous system in intestinal inflammation |
| url | http://dx.doi.org/10.1155/1996/502865 |
| work_keys_str_mv | AT keithasharkey theentericnervoussysteminintestinalinflammation AT edwardjparr theentericnervoussysteminintestinalinflammation AT keithasharkey entericnervoussysteminintestinalinflammation AT edwardjparr entericnervoussysteminintestinalinflammation |