Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cance...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.3233/ACP-CLO-2010-0549 |
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| author | Bodvael Pennarun Jan H. Kleibeuker Tjitske Oenema Janet H. Stegehuis Elisabeth G.E. de Vries Steven de Jong |
| author_facet | Bodvael Pennarun Jan H. Kleibeuker Tjitske Oenema Janet H. Stegehuis Elisabeth G.E. de Vries Steven de Jong |
| author_sort | Bodvael Pennarun |
| collection | DOAJ |
| description | Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cancer, influencing both cell proliferation and apoptosis. We hypothesized that inhibiting the IGF-1 receptor (IGF-1R) using NVP-AEW541, a small molecular weight tyrosine kinase inhibitor of the IGF-1R, could increase death receptor (DR)-mediated apoptosis in colon cancer cells. |
| format | Article |
| id | doaj-art-4c4172c9127e433aad30315e20b40f58 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-4c4172c9127e433aad30315e20b40f582025-02-03T01:01:41ZengWileyAnalytical Cellular Pathology2210-71772210-71852010-01-01335-622924410.3233/ACP-CLO-2010-0549Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAILBodvael Pennarun0Jan H. Kleibeuker1Tjitske Oenema2Janet H. Stegehuis3Elisabeth G.E. de Vries4Steven de Jong5Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Gastroenterology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsBackground: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cancer, influencing both cell proliferation and apoptosis. We hypothesized that inhibiting the IGF-1 receptor (IGF-1R) using NVP-AEW541, a small molecular weight tyrosine kinase inhibitor of the IGF-1R, could increase death receptor (DR)-mediated apoptosis in colon cancer cells.http://dx.doi.org/10.3233/ACP-CLO-2010-0549 |
| spellingShingle | Bodvael Pennarun Jan H. Kleibeuker Tjitske Oenema Janet H. Stegehuis Elisabeth G.E. de Vries Steven de Jong Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL Analytical Cellular Pathology |
| title | Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL |
| title_full | Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL |
| title_fullStr | Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL |
| title_full_unstemmed | Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL |
| title_short | Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL |
| title_sort | inhibition of igf 1r dependent pi3k activation sensitizes colon cancer cells specifically to dr5 mediated apoptosis but not to rhtrail |
| url | http://dx.doi.org/10.3233/ACP-CLO-2010-0549 |
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