Cold induces brain region-selective cell activity-dependent lipid metabolism
It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system lipid dynamics is underexplored. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue lipid lipolysis and beigi...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2025-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/98353 |
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| author | Hyeonyoung Min Yale Y Yang Yunlei Yang |
| author_facet | Hyeonyoung Min Yale Y Yang Yunlei Yang |
| author_sort | Hyeonyoung Min |
| collection | DOAJ |
| description | It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system lipid dynamics is underexplored. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue lipid lipolysis and beiging, and brown adipose tissue thermogenesis in mammals. However, it remains unclear whether and how lipid metabolism in the brain is also under the control of ambient temperature. Here, we show that cold exposure predominantly increases the expressions of the lipid lipolysis genes and proteins within the paraventricular nucleus of the hypothalamus (PVH) in male mice. Mechanistically, by using innovatively combined brain-region selective pharmacology and in vivo time-lapse photometry monitoring of lipid metabolism, we find that cold activates cells within the PVH and pharmacological inactivation of cells blunts cold-induced effects on lipid peroxidation, accumulation of lipid droplets, and lipid lipolysis in the PVH. Together, these findings suggest that PVH lipid metabolism is cold sensitive and integral to cold-induced broader regulatory responses. |
| format | Article |
| id | doaj-art-4c3a321f54ed434e887703926efabc87 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-4c3a321f54ed434e887703926efabc872025-01-30T13:21:23ZengeLife Sciences Publications LtdeLife2050-084X2025-01-011310.7554/eLife.98353Cold induces brain region-selective cell activity-dependent lipid metabolismHyeonyoung Min0Yale Y Yang1Yunlei Yang2https://orcid.org/0000-0002-7623-6680Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, United StatesFriends Seminary, New York, United StatesDepartment of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, United States; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States; The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, United StatesIt has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system lipid dynamics is underexplored. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue lipid lipolysis and beiging, and brown adipose tissue thermogenesis in mammals. However, it remains unclear whether and how lipid metabolism in the brain is also under the control of ambient temperature. Here, we show that cold exposure predominantly increases the expressions of the lipid lipolysis genes and proteins within the paraventricular nucleus of the hypothalamus (PVH) in male mice. Mechanistically, by using innovatively combined brain-region selective pharmacology and in vivo time-lapse photometry monitoring of lipid metabolism, we find that cold activates cells within the PVH and pharmacological inactivation of cells blunts cold-induced effects on lipid peroxidation, accumulation of lipid droplets, and lipid lipolysis in the PVH. Together, these findings suggest that PVH lipid metabolism is cold sensitive and integral to cold-induced broader regulatory responses.https://elifesciences.org/articles/98353coldlipid metabolismparaventricular of hypothalamusphotometry |
| spellingShingle | Hyeonyoung Min Yale Y Yang Yunlei Yang Cold induces brain region-selective cell activity-dependent lipid metabolism eLife cold lipid metabolism paraventricular of hypothalamus photometry |
| title | Cold induces brain region-selective cell activity-dependent lipid metabolism |
| title_full | Cold induces brain region-selective cell activity-dependent lipid metabolism |
| title_fullStr | Cold induces brain region-selective cell activity-dependent lipid metabolism |
| title_full_unstemmed | Cold induces brain region-selective cell activity-dependent lipid metabolism |
| title_short | Cold induces brain region-selective cell activity-dependent lipid metabolism |
| title_sort | cold induces brain region selective cell activity dependent lipid metabolism |
| topic | cold lipid metabolism paraventricular of hypothalamus photometry |
| url | https://elifesciences.org/articles/98353 |
| work_keys_str_mv | AT hyeonyoungmin coldinducesbrainregionselectivecellactivitydependentlipidmetabolism AT yaleyyang coldinducesbrainregionselectivecellactivitydependentlipidmetabolism AT yunleiyang coldinducesbrainregionselectivecellactivitydependentlipidmetabolism |