Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus
In the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). The study included 81 children and adole...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/614908 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560240547069952 |
|---|---|
| author | Katarzyna Zorena Ewa Malinowska Dorota Raczyńska Małgorzata Myśliwiec Krystyna Raczyńska |
| author_facet | Katarzyna Zorena Ewa Malinowska Dorota Raczyńska Małgorzata Myśliwiec Krystyna Raczyńska |
| author_sort | Katarzyna Zorena |
| collection | DOAJ |
| description | In the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). The study included 81 children and adolescents with T1DM and 19 control subjects. All study participants had biochemical parameters examined, underwent an eye examination, and 24-hour blood pressure monitoring. Moreover, serum concentrations of TGF-β1 were measured. The group of patients with T1DM and nonproliferative diabetic retinopathy (NPDR) had statistically significant higher serum levels of TGF-β1 (P=0.001) as compared to T1DM patients without retinopathy as well as the healthy control subject. The threshold serum TGF-β1 concentrations which had a discriminative ability to predict the presence of DR were calculated using the receiver operating characteristic (ROC) curves analysis and amounted to 443 pg/ml. The area under the ROC curve (AUCROC) was 0.80, and its population value was in the range of 0.66 to 0.94. The sensitivity and specificity were calculated to be 72% and 88%, respectively. Our results suggest that TGF-β1 serum concentrations may be an additional parameter in predicting the occurrence of DR in juvenile patients with T1DM. |
| format | Article |
| id | doaj-art-4c37af4de7fa4a32acf166dd925c1415 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4c37af4de7fa4a32acf166dd925c14152025-02-03T01:28:02ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/614908614908Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes MellitusKatarzyna Zorena0Ewa Malinowska1Dorota Raczyńska2Małgorzata Myśliwiec3Krystyna Raczyńska4Department of Clinical and Experimental Endocrinology, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, Powstania Styczniowego 9b, 81-519 Gdynia, PolandDepartment of Immunology, Medical University of Gdańsk, Gdańsk, PolandDepartment and Clinic of Ophthalmology, Medical University of Gdańsk, Gdańsk, PolandDepartment and Clinic of Pediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Gdańsk, PolandDepartment and Clinic of Ophthalmology, Medical University of Gdańsk, Gdańsk, PolandIn the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). The study included 81 children and adolescents with T1DM and 19 control subjects. All study participants had biochemical parameters examined, underwent an eye examination, and 24-hour blood pressure monitoring. Moreover, serum concentrations of TGF-β1 were measured. The group of patients with T1DM and nonproliferative diabetic retinopathy (NPDR) had statistically significant higher serum levels of TGF-β1 (P=0.001) as compared to T1DM patients without retinopathy as well as the healthy control subject. The threshold serum TGF-β1 concentrations which had a discriminative ability to predict the presence of DR were calculated using the receiver operating characteristic (ROC) curves analysis and amounted to 443 pg/ml. The area under the ROC curve (AUCROC) was 0.80, and its population value was in the range of 0.66 to 0.94. The sensitivity and specificity were calculated to be 72% and 88%, respectively. Our results suggest that TGF-β1 serum concentrations may be an additional parameter in predicting the occurrence of DR in juvenile patients with T1DM.http://dx.doi.org/10.1155/2013/614908 |
| spellingShingle | Katarzyna Zorena Ewa Malinowska Dorota Raczyńska Małgorzata Myśliwiec Krystyna Raczyńska Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus Journal of Diabetes Research |
| title | Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus |
| title_full | Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus |
| title_fullStr | Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus |
| title_full_unstemmed | Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus |
| title_short | Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus |
| title_sort | serum concentrations of transforming growth factor beta 1 in predicting the occurrence of diabetic retinopathy in juvenile patients with type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/614908 |
| work_keys_str_mv | AT katarzynazorena serumconcentrationsoftransforminggrowthfactorbeta1inpredictingtheoccurrenceofdiabeticretinopathyinjuvenilepatientswithtype1diabetesmellitus AT ewamalinowska serumconcentrationsoftransforminggrowthfactorbeta1inpredictingtheoccurrenceofdiabeticretinopathyinjuvenilepatientswithtype1diabetesmellitus AT dorotaraczynska serumconcentrationsoftransforminggrowthfactorbeta1inpredictingtheoccurrenceofdiabeticretinopathyinjuvenilepatientswithtype1diabetesmellitus AT małgorzatamysliwiec serumconcentrationsoftransforminggrowthfactorbeta1inpredictingtheoccurrenceofdiabeticretinopathyinjuvenilepatientswithtype1diabetesmellitus AT krystynaraczynska serumconcentrationsoftransforminggrowthfactorbeta1inpredictingtheoccurrenceofdiabeticretinopathyinjuvenilepatientswithtype1diabetesmellitus |