Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging
IntroductionHippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in h...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1535158/full |
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| author | Maggie K. Pecsok Heather Robinson Ally Atkins Monica E. Calkins Monica E. Calkins Mark A. Elliott Arianna Mordy Jacquelyn Stifelman Ruben C. Gur Ruben C. Gur Paul J. Moberg Ravi Prakash Reddy Nanga Kosha Ruparel Kosha Ruparel Russell T. Shinohara David A. Wolk Ravinder Reddy David R. Roalf David R. Roalf |
| author_facet | Maggie K. Pecsok Heather Robinson Ally Atkins Monica E. Calkins Monica E. Calkins Mark A. Elliott Arianna Mordy Jacquelyn Stifelman Ruben C. Gur Ruben C. Gur Paul J. Moberg Ravi Prakash Reddy Nanga Kosha Ruparel Kosha Ruparel Russell T. Shinohara David A. Wolk Ravinder Reddy David R. Roalf David R. Roalf |
| author_sort | Maggie K. Pecsok |
| collection | DOAJ |
| description | IntroductionHippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in healthy old (HOA) and young (HYA) adults.MethodsBilateral hippocampal GluCEST data was acquired from 27 HOA and 22 HYA using 7T MRI. GluCEST differences by age and hemisphere were tested with a linear mixed model. GluCEST asymmetry index was also evaluated by age. Exploratory analyses examined associations between hippocampal GluCEST, age group, and scores on the Montreal Cognitive Assessment (MoCA) and Cognitive Complaints Index (CCI).ResultsGluCEST levels showed an age group and hemisphere interaction. In HOA, GluCEST was higher in left than right hippocampus, but in HYA, GluCEST level was equivalent across hemispheres. HOA had lower GluCEST than HYA in the right hippocampus. GluCEST asymmetry index confirmed significant left asymmetry in HOA. Lower GluCEST levels in HOA were associated with subjective cognitive complaints as measured by the CCI.DiscussionHippocampal GluCEST provides insight into age-related neural changes, with lower GluCEST in the right hippocampus in older adults. These findings offer a step toward elucidating the asymmetrical trajectory of hippocampal glutamatergic alterations and their relationship to cognitive phenotypes. |
| format | Article |
| id | doaj-art-4c26bcfc3c134288abdf7034e196b230 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-4c26bcfc3c134288abdf7034e196b2302025-01-24T07:13:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011610.3389/fnagi.2024.15351581535158Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imagingMaggie K. Pecsok0Heather Robinson1Ally Atkins2Monica E. Calkins3Monica E. Calkins4Mark A. Elliott5Arianna Mordy6Jacquelyn Stifelman7Ruben C. Gur8Ruben C. Gur9Paul J. Moberg10Ravi Prakash Reddy Nanga11Kosha Ruparel12Kosha Ruparel13Russell T. Shinohara14David A. Wolk15Ravinder Reddy16David R. Roalf17David R. Roalf18Brain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesDepartment of Psychological Sciences, Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, CT, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Lifespan Brain Institute (LiBI) of CHOP and Penn Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCognitive and Clinical Neuroscience Lab, UCLA Brain Mapping Center, Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Lifespan Brain Institute (LiBI) of CHOP and Penn Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Lifespan Brain Institute (LiBI) of CHOP and Penn Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesPenn Statistics in Imaging and Visualization Endeavor (PennSIVE), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesPenn Memory Center and Alzheimer's Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesBrain and Behavior Lab, Neurodevelopment and Psychosis Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Lifespan Brain Institute (LiBI) of CHOP and Penn Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesIntroductionHippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in healthy old (HOA) and young (HYA) adults.MethodsBilateral hippocampal GluCEST data was acquired from 27 HOA and 22 HYA using 7T MRI. GluCEST differences by age and hemisphere were tested with a linear mixed model. GluCEST asymmetry index was also evaluated by age. Exploratory analyses examined associations between hippocampal GluCEST, age group, and scores on the Montreal Cognitive Assessment (MoCA) and Cognitive Complaints Index (CCI).ResultsGluCEST levels showed an age group and hemisphere interaction. In HOA, GluCEST was higher in left than right hippocampus, but in HYA, GluCEST level was equivalent across hemispheres. HOA had lower GluCEST than HYA in the right hippocampus. GluCEST asymmetry index confirmed significant left asymmetry in HOA. Lower GluCEST levels in HOA were associated with subjective cognitive complaints as measured by the CCI.DiscussionHippocampal GluCEST provides insight into age-related neural changes, with lower GluCEST in the right hippocampus in older adults. These findings offer a step toward elucidating the asymmetrical trajectory of hippocampal glutamatergic alterations and their relationship to cognitive phenotypes.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1535158/fullglutamateaging7Tesla MRIGluCESThippocampus |
| spellingShingle | Maggie K. Pecsok Heather Robinson Ally Atkins Monica E. Calkins Monica E. Calkins Mark A. Elliott Arianna Mordy Jacquelyn Stifelman Ruben C. Gur Ruben C. Gur Paul J. Moberg Ravi Prakash Reddy Nanga Kosha Ruparel Kosha Ruparel Russell T. Shinohara David A. Wolk Ravinder Reddy David R. Roalf David R. Roalf Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging Frontiers in Aging Neuroscience glutamate aging 7Tesla MRI GluCEST hippocampus |
| title | Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging |
| title_full | Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging |
| title_fullStr | Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging |
| title_full_unstemmed | Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging |
| title_short | Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging |
| title_sort | mapping hippocampal glutamate in healthy aging with in vivo glutamate weighted cest glucest imaging |
| topic | glutamate aging 7Tesla MRI GluCEST hippocampus |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1535158/full |
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