Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways
As cervical cancer is one of the most common malignancies in women worldwide even with present screening methods, the incidence in most developed countries is not decreasing for the last 15-20 years. A shift has been observed in the age of diagnosis in favour of younger women, and treatment of alrea...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2607594 |
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| _version_ | 1832566124306235392 |
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| author | Aleksander Celewicz Marta Celewicz Michał Michalczyk Rafał Rzepka |
| author_facet | Aleksander Celewicz Marta Celewicz Michał Michalczyk Rafał Rzepka |
| author_sort | Aleksander Celewicz |
| collection | DOAJ |
| description | As cervical cancer is one of the most common malignancies in women worldwide even with present screening methods, the incidence in most developed countries is not decreasing for the last 15-20 years. A shift has been observed in the age of diagnosis in favour of younger women, and treatment of already developed cervical cancer is a challenge for surgeons. It is imperative to find new diagnostic methods for accurately pointing out patients at high risk of developing malignant disease and developing personalized treatment. Since cervical cancer is almost exclusively associated with HPV infection, understanding changes happening in an infected cell may prove invaluable for search of such methods, but it may also prove helpful in the diagnosis and treatment of other anogenital and nasopharyngeal region cancers. This review follows HPV-related changes in infected cell biology to point what potential markers and targets for therapy are in option when dealing with HPV-related diseases. |
| format | Article |
| id | doaj-art-4c2200fc570b4ba8ae9110726312b341 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4c2200fc570b4ba8ae9110726312b3412025-02-03T01:05:01ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/26075942607594Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis PathwaysAleksander Celewicz0Marta Celewicz1Michał Michalczyk2Rafał Rzepka3Department of Gynecology and Obstetrics, Collegium Medicum University of Zielona Góra, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University, PolandDepartment of Gynecology and Obstetrics, Collegium Medicum University of Zielona Góra, PolandDepartment of Gynecology and Obstetrics, Collegium Medicum University of Zielona Góra, PolandAs cervical cancer is one of the most common malignancies in women worldwide even with present screening methods, the incidence in most developed countries is not decreasing for the last 15-20 years. A shift has been observed in the age of diagnosis in favour of younger women, and treatment of already developed cervical cancer is a challenge for surgeons. It is imperative to find new diagnostic methods for accurately pointing out patients at high risk of developing malignant disease and developing personalized treatment. Since cervical cancer is almost exclusively associated with HPV infection, understanding changes happening in an infected cell may prove invaluable for search of such methods, but it may also prove helpful in the diagnosis and treatment of other anogenital and nasopharyngeal region cancers. This review follows HPV-related changes in infected cell biology to point what potential markers and targets for therapy are in option when dealing with HPV-related diseases.http://dx.doi.org/10.1155/2020/2607594 |
| spellingShingle | Aleksander Celewicz Marta Celewicz Michał Michalczyk Rafał Rzepka Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways Mediators of Inflammation |
| title | Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways |
| title_full | Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways |
| title_fullStr | Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways |
| title_full_unstemmed | Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways |
| title_short | Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways |
| title_sort | perspectives in hpv secondary screening and personalized therapy basing on our understanding of hpv related carcinogenesis pathways |
| url | http://dx.doi.org/10.1155/2020/2607594 |
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