Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis
The efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis. Patients were enrolled in an open-label compassionate use program. One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activity ind...
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| Format: | Article |
| Language: | English |
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Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/314931 |
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| author | MG Robinson DL Decktor |
| author_facet | MG Robinson DL Decktor |
| author_sort | MG Robinson |
| collection | DOAJ |
| description | The efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine)
enemas was assessed in 666 patients with distal ulcerative colitis. Patients were
enrolled in an open-label compassionate use program. One 4 g 5-ASA enema
was administered each night for a period of four weeks and the disease activity
index was assessed at baseline and on days 14 and 28. On days 14 and 28, 78.0%
and 88.1% of patients, respectively, demonstrated an improvement in disease
activity index. The mean decline in disease activity index on day 14 was 40.7%
(P=0.0001) and on day 28 it was 55.4% (P=0.0001). Efficacy was similar whether
the disease was confined to or extended beyond 30 cm from the anus. There was
no difference in efficacy in patients suffering their first episode of disease
compared to patients suffering subsequent attacks. In conclusion, high dose
5-ASA enemas are a highly effective treatment for distal ulcerative colitis. |
| format | Article |
| id | doaj-art-4c1e12836e334d18a5ba6f4d404e5474 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4c1e12836e334d18a5ba6f4d404e54742025-02-03T01:22:34ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-014746847110.1155/1990/314931Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative ColitisMG RobinsonDL DecktorThe efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis. Patients were enrolled in an open-label compassionate use program. One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activity index was assessed at baseline and on days 14 and 28. On days 14 and 28, 78.0% and 88.1% of patients, respectively, demonstrated an improvement in disease activity index. The mean decline in disease activity index on day 14 was 40.7% (P=0.0001) and on day 28 it was 55.4% (P=0.0001). Efficacy was similar whether the disease was confined to or extended beyond 30 cm from the anus. There was no difference in efficacy in patients suffering their first episode of disease compared to patients suffering subsequent attacks. In conclusion, high dose 5-ASA enemas are a highly effective treatment for distal ulcerative colitis.http://dx.doi.org/10.1155/1990/314931 |
| spellingShingle | MG Robinson DL Decktor Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis Canadian Journal of Gastroenterology |
| title | Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis |
| title_full | Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis |
| title_fullStr | Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis |
| title_full_unstemmed | Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis |
| title_short | Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis |
| title_sort | efficacy of 5 aminosalicylic acid enemas in the treatment of distal ulcerative colitis |
| url | http://dx.doi.org/10.1155/1990/314931 |
| work_keys_str_mv | AT mgrobinson efficacyof5aminosalicylicacidenemasinthetreatmentofdistalulcerativecolitis AT dldecktor efficacyof5aminosalicylicacidenemasinthetreatmentofdistalulcerativecolitis |