Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients
Background and aimsThis research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.MethodsFrom August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1519686/full |
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| author | Suxian Zhao Chen Dong Chudi Chang Jiaming Zhang Jing Li Xiaoxiao Zhang Weiguang Ren Ying Zhang Yuemin Nan |
| author_facet | Suxian Zhao Chen Dong Chudi Chang Jiaming Zhang Jing Li Xiaoxiao Zhang Weiguang Ren Ying Zhang Yuemin Nan |
| author_sort | Suxian Zhao |
| collection | DOAJ |
| description | Background and aimsThis research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.MethodsFrom August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and viral indicators as well as hepatic inflammation biomarkers were monitored.ResultsIn total, 55 CHB patients were enrolled. The average HBV-cccDNA level was markedly elevated in HBeAg+ patients compared to HBeAg patients. Intrahepatic cccDNA levels differed significantly in different liver inflammation groups and showed a positive correlation with the HAI score for hepatic inflammation.ConclusionHBV-cccDNA level was associated with liver inflammation. |
| format | Article |
| id | doaj-art-4c1da3674f124af79a6894bbcbcd18ad |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-4c1da3674f124af79a6894bbcbcd18ad2025-01-24T07:13:49ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15196861519686Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patientsSuxian ZhaoChen DongChudi ChangJiaming ZhangJing LiXiaoxiao ZhangWeiguang RenYing ZhangYuemin NanBackground and aimsThis research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.MethodsFrom August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and viral indicators as well as hepatic inflammation biomarkers were monitored.ResultsIn total, 55 CHB patients were enrolled. The average HBV-cccDNA level was markedly elevated in HBeAg+ patients compared to HBeAg patients. Intrahepatic cccDNA levels differed significantly in different liver inflammation groups and showed a positive correlation with the HAI score for hepatic inflammation.ConclusionHBV-cccDNA level was associated with liver inflammation.https://www.frontiersin.org/articles/10.3389/fmed.2024.1519686/fullcovalently closed circular DNA (cccDNA)inflammationliverHBVchronic hepatitis B |
| spellingShingle | Suxian Zhao Chen Dong Chudi Chang Jiaming Zhang Jing Li Xiaoxiao Zhang Weiguang Ren Ying Zhang Yuemin Nan Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients Frontiers in Medicine covalently closed circular DNA (cccDNA) inflammation liver HBV chronic hepatitis B |
| title | Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients |
| title_full | Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients |
| title_fullStr | Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients |
| title_full_unstemmed | Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients |
| title_short | Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients |
| title_sort | association between intrahepatic cccdna and the severity of liver inflammation in chronic hepatitis b virus infection patients |
| topic | covalently closed circular DNA (cccDNA) inflammation liver HBV chronic hepatitis B |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1519686/full |
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