Targeting lipid metabolism of macrophages: A new strategy for tumor therapy
Background: Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development of multiple diseases, including tumor. Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224000717 |
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| author | Nan Shao Hui Qiu Jing Liu Daimin Xiao Juanjuan Zhao Chao Chen Jiajia Wan Mengmeng Guo Guiyou Liang Xu Zhao Lin Xu |
| author_facet | Nan Shao Hui Qiu Jing Liu Daimin Xiao Juanjuan Zhao Chao Chen Jiajia Wan Mengmeng Guo Guiyou Liang Xu Zhao Lin Xu |
| author_sort | Nan Shao |
| collection | DOAJ |
| description | Background: Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development of multiple diseases, including tumor. Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. Accumulating evidence has shown that lipid metabolic reprogramming, including fatty acid uptake and utilization, cholesterol expulsion, controls the polarization of TAMs and affects the tumorgenesis. These advances in uncovering the intricacies of lipid metabolism and TAMs have yielded new insights on tumor development and treatment. In this review, we aim to provide an update on the current understanding of the lipid metabolic reprogramming made by TAMs to adapt to the harsh tumor microenvironment (TME). In particular, we emphasize that there is complex lipid metabolism connections between TAMs and distinct tumors, which influences TAM to bias from M1 to M2 phenotype in tumor progression, and ultimately promotes tumor occurrence and development. Finally, we discuss the existing issues on therapeutic strategies by reprogramming TAMs based on lipid metabolism regulation (or increasing the ratio of M1/M2-like TAMs) that could be applied in the future to clinical tumor treatment. |
| format | Article |
| id | doaj-art-4c175bf075e64057adbf4814a3030c1f |
| institution | Kabale University |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-4c175bf075e64057adbf4814a3030c1f2025-01-18T05:04:18ZengElsevierJournal of Advanced Research2090-12322025-02-016899114Targeting lipid metabolism of macrophages: A new strategy for tumor therapyNan Shao0Hui Qiu1Jing Liu2Daimin Xiao3Juanjuan Zhao4Chao Chen5Jiajia Wan6Mengmeng Guo7Guiyou Liang8Xu Zhao9Lin Xu10Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaSpecial Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, ChinaDepartment of Cardiovascular Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550031, China; Corresponding authors at: School of Medicine, Guizhou University, Guizhou, Guiyang 550025, China (X. Zhao); Department of immunology, Zunyi Medical University, GuiZhou, Zunyi 563003, China (L. Xu); Department of Cardiovascular Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550031, China (G. Liang).School of Medicine, Guizhou University, Guizhou, Guiyang 550025, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Corresponding authors at: School of Medicine, Guizhou University, Guizhou, Guiyang 550025, China (X. Zhao); Department of immunology, Zunyi Medical University, GuiZhou, Zunyi 563003, China (L. Xu); Department of Cardiovascular Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550031, China (G. Liang).Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, China; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, Guizhou 563000, China; Corresponding authors at: School of Medicine, Guizhou University, Guizhou, Guiyang 550025, China (X. Zhao); Department of immunology, Zunyi Medical University, GuiZhou, Zunyi 563003, China (L. Xu); Department of Cardiovascular Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550031, China (G. Liang).Background: Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development of multiple diseases, including tumor. Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. Accumulating evidence has shown that lipid metabolic reprogramming, including fatty acid uptake and utilization, cholesterol expulsion, controls the polarization of TAMs and affects the tumorgenesis. These advances in uncovering the intricacies of lipid metabolism and TAMs have yielded new insights on tumor development and treatment. In this review, we aim to provide an update on the current understanding of the lipid metabolic reprogramming made by TAMs to adapt to the harsh tumor microenvironment (TME). In particular, we emphasize that there is complex lipid metabolism connections between TAMs and distinct tumors, which influences TAM to bias from M1 to M2 phenotype in tumor progression, and ultimately promotes tumor occurrence and development. Finally, we discuss the existing issues on therapeutic strategies by reprogramming TAMs based on lipid metabolism regulation (or increasing the ratio of M1/M2-like TAMs) that could be applied in the future to clinical tumor treatment.http://www.sciencedirect.com/science/article/pii/S2090123224000717Tumor-associated macrophageLipid metabolismPolarizationReprogrammingTumor |
| spellingShingle | Nan Shao Hui Qiu Jing Liu Daimin Xiao Juanjuan Zhao Chao Chen Jiajia Wan Mengmeng Guo Guiyou Liang Xu Zhao Lin Xu Targeting lipid metabolism of macrophages: A new strategy for tumor therapy Journal of Advanced Research Tumor-associated macrophage Lipid metabolism Polarization Reprogramming Tumor |
| title | Targeting lipid metabolism of macrophages: A new strategy for tumor therapy |
| title_full | Targeting lipid metabolism of macrophages: A new strategy for tumor therapy |
| title_fullStr | Targeting lipid metabolism of macrophages: A new strategy for tumor therapy |
| title_full_unstemmed | Targeting lipid metabolism of macrophages: A new strategy for tumor therapy |
| title_short | Targeting lipid metabolism of macrophages: A new strategy for tumor therapy |
| title_sort | targeting lipid metabolism of macrophages a new strategy for tumor therapy |
| topic | Tumor-associated macrophage Lipid metabolism Polarization Reprogramming Tumor |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224000717 |
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