Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention
Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000130 |
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| author | Xuan Lu Ying Chen Yue Shi Yi Shi Xianbin Su Peijie Chen Die Wu Hui Shi |
| author_facet | Xuan Lu Ying Chen Yue Shi Yi Shi Xianbin Su Peijie Chen Die Wu Hui Shi |
| author_sort | Xuan Lu |
| collection | DOAJ |
| description | Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging. This review provides a comprehensive summary of different forms of exercise for older adults and the multifaceted role of exercise in anti-aging, focusing on the biological functions and sources of these exerkines. We further explore how exerkines combat aging-related diseases, such as type 2 diabetes and osteoporosis. By stimulating the secretion of these exerkines, exercise supports healthy longevity by promoting tissue homeostasis and metabolic balance. Additionally, the integration of exercise-induced exerkines into therapeutic strategies represents a promising approach to mitigating age-related pathologies at the molecular level. As our understanding deepens, it may pave the way for personalized interventions leveraging physical activity to enhance healthspan and improve quality of life. |
| format | Article |
| id | doaj-art-4c171603ff0a497d89973b9a37df2737 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-4c171603ff0a497d89973b9a37df27372025-01-31T05:10:09ZengElsevierExperimental Gerontology1873-68152025-02-01200112685Exercise and exerkines: Mechanisms and roles in anti-aging and disease preventionXuan Lu0Ying Chen1Yue Shi2Yi Shi3Xianbin Su4Peijie Chen5Die Wu6Hui Shi7Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, ChinaShanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Athletic, Shanghai University of Sport, Shanghai 200438, ChinaBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, ChinaKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaShanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Corresponding authors.Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Corresponding authors.Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Correspondence to: H. Shi, Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging. This review provides a comprehensive summary of different forms of exercise for older adults and the multifaceted role of exercise in anti-aging, focusing on the biological functions and sources of these exerkines. We further explore how exerkines combat aging-related diseases, such as type 2 diabetes and osteoporosis. By stimulating the secretion of these exerkines, exercise supports healthy longevity by promoting tissue homeostasis and metabolic balance. Additionally, the integration of exercise-induced exerkines into therapeutic strategies represents a promising approach to mitigating age-related pathologies at the molecular level. As our understanding deepens, it may pave the way for personalized interventions leveraging physical activity to enhance healthspan and improve quality of life.http://www.sciencedirect.com/science/article/pii/S0531556525000130ExerkinesAnti-agingExercise physiology |
| spellingShingle | Xuan Lu Ying Chen Yue Shi Yi Shi Xianbin Su Peijie Chen Die Wu Hui Shi Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention Experimental Gerontology Exerkines Anti-aging Exercise physiology |
| title | Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention |
| title_full | Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention |
| title_fullStr | Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention |
| title_full_unstemmed | Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention |
| title_short | Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention |
| title_sort | exercise and exerkines mechanisms and roles in anti aging and disease prevention |
| topic | Exerkines Anti-aging Exercise physiology |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000130 |
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