TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2

TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2

Sleep deprivation (SD) contributes to cognitive impairment. Astrocytic cholesterol biosynthesis is crucial for brain cholesterol homeostasis and cognitive function. However, the underlying mechanism of astrocytic cholesterol metabolism in SD-induced cognitive impairment has not been fully explored....

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Bibliographic Details
Main Authors: Shan Zhu, Yue Wang, Yansong Li, Na Li, Yige Zheng, Qiao Li, Hongyan Guo, Jianyu Sun, Qian Zhai, Yaomin Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
sleep deprivation
FMO3
TMAO
SREBP2
astrocytes
cholesterol metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1499591/full
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