IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients
Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 heal...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/819149 |
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| author | Priscilla Stela Santana de Oliveira Pablo Ramon Gualberto Cardoso Emerson Vasconcelos de Andrade Lima Michelly Cristiny Pereira Angela Luzia Branco Pinto Duarte Ivan da Rocha Pitta Moacyr Jesus Barreto de Melo Rêgo Maira Galdino da Rocha Pitta |
| author_facet | Priscilla Stela Santana de Oliveira Pablo Ramon Gualberto Cardoso Emerson Vasconcelos de Andrade Lima Michelly Cristiny Pereira Angela Luzia Branco Pinto Duarte Ivan da Rocha Pitta Moacyr Jesus Barreto de Melo Rêgo Maira Galdino da Rocha Pitta |
| author_sort | Priscilla Stela Santana de Oliveira |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokine detection. Psoriasis Area and Severity Index (PASI) was assessed at the time of sampling in psoriasis patients. Our findings demonstrate that IL-17A, IL-22, and IL-6 serum concentrations were significantly higher in psoriasis patients than in the control group. No statistical correlation could be found between cytokines concentrations, PASI score, and age in this study. Although our results do not show any correlation between serum levels of IL-17A, IL-22, and IL-6 and disease activity, the present study confirms that they were increased in Brazilian psoriasis patients in comparison to healthy volunteers. |
| format | Article |
| id | doaj-art-4bf03a4af83b4a07a4203c3876b0a37e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4bf03a4af83b4a07a4203c3876b0a37e2025-02-03T05:51:36ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/819149819149IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian PatientsPriscilla Stela Santana de Oliveira0Pablo Ramon Gualberto Cardoso1Emerson Vasconcelos de Andrade Lima2Michelly Cristiny Pereira3Angela Luzia Branco Pinto Duarte4Ivan da Rocha Pitta5Moacyr Jesus Barreto de Melo Rêgo6Maira Galdino da Rocha Pitta7Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilHospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilHospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilPsoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokine detection. Psoriasis Area and Severity Index (PASI) was assessed at the time of sampling in psoriasis patients. Our findings demonstrate that IL-17A, IL-22, and IL-6 serum concentrations were significantly higher in psoriasis patients than in the control group. No statistical correlation could be found between cytokines concentrations, PASI score, and age in this study. Although our results do not show any correlation between serum levels of IL-17A, IL-22, and IL-6 and disease activity, the present study confirms that they were increased in Brazilian psoriasis patients in comparison to healthy volunteers.http://dx.doi.org/10.1155/2015/819149 |
| spellingShingle | Priscilla Stela Santana de Oliveira Pablo Ramon Gualberto Cardoso Emerson Vasconcelos de Andrade Lima Michelly Cristiny Pereira Angela Luzia Branco Pinto Duarte Ivan da Rocha Pitta Moacyr Jesus Barreto de Melo Rêgo Maira Galdino da Rocha Pitta IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients Mediators of Inflammation |
| title | IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients |
| title_full | IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients |
| title_fullStr | IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients |
| title_full_unstemmed | IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients |
| title_short | IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients |
| title_sort | il 17a il 22 il 6 and il 21 serum levels in plaque type psoriasis in brazilian patients |
| url | http://dx.doi.org/10.1155/2015/819149 |
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