Emerging role of exosomes in cancer therapy: progress and challenges
Abstract This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenici...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-024-02215-4 |
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| author | Jiale Li Jiachong Wang Zigui Chen |
| author_facet | Jiale Li Jiachong Wang Zigui Chen |
| author_sort | Jiale Li |
| collection | DOAJ |
| description | Abstract This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity, making them ideal drug delivery vehicles capable of efficiently targeting cancer cells, minimizing off-target damage and side effects. This review aims to explore the potential of exosomes in cancer therapy, with a focus on applications in chemotherapy, gene therapy, and immunomodulation. Additionally, challenges related to exosome production and standardization are analyzed, highlighting the importance of addressing these issues for their clinical application. In conclusion, exosome-based drug delivery systems offer promising potential for future cancer therapies. Further research should aim to enhance production efficiency and facilitate clinical translation, paving the way for innovative cancer treatment strategies. |
| format | Article |
| id | doaj-art-4bd073a48a7a47ba97bfdaf2e79238d8 |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-4bd073a48a7a47ba97bfdaf2e79238d82025-01-19T12:12:34ZengBMCMolecular Cancer1476-45982025-01-0124113410.1186/s12943-024-02215-4Emerging role of exosomes in cancer therapy: progress and challengesJiale Li0Jiachong Wang1Zigui Chen2Department of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of MedicineDepartment of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of MedicineDepartment of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of MedicineAbstract This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity, making them ideal drug delivery vehicles capable of efficiently targeting cancer cells, minimizing off-target damage and side effects. This review aims to explore the potential of exosomes in cancer therapy, with a focus on applications in chemotherapy, gene therapy, and immunomodulation. Additionally, challenges related to exosome production and standardization are analyzed, highlighting the importance of addressing these issues for their clinical application. In conclusion, exosome-based drug delivery systems offer promising potential for future cancer therapies. Further research should aim to enhance production efficiency and facilitate clinical translation, paving the way for innovative cancer treatment strategies.https://doi.org/10.1186/s12943-024-02215-4ExosomesExosome-based drug deliveryCancer therapyClinical application |
| spellingShingle | Jiale Li Jiachong Wang Zigui Chen Emerging role of exosomes in cancer therapy: progress and challenges Molecular Cancer Exosomes Exosome-based drug delivery Cancer therapy Clinical application |
| title | Emerging role of exosomes in cancer therapy: progress and challenges |
| title_full | Emerging role of exosomes in cancer therapy: progress and challenges |
| title_fullStr | Emerging role of exosomes in cancer therapy: progress and challenges |
| title_full_unstemmed | Emerging role of exosomes in cancer therapy: progress and challenges |
| title_short | Emerging role of exosomes in cancer therapy: progress and challenges |
| title_sort | emerging role of exosomes in cancer therapy progress and challenges |
| topic | Exosomes Exosome-based drug delivery Cancer therapy Clinical application |
| url | https://doi.org/10.1186/s12943-024-02215-4 |
| work_keys_str_mv | AT jialeli emergingroleofexosomesincancertherapyprogressandchallenges AT jiachongwang emergingroleofexosomesincancertherapyprogressandchallenges AT ziguichen emergingroleofexosomesincancertherapyprogressandchallenges |