Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity
ABSTRACT Objectives To investigate neural responsiveness to electrical stimulation in children with common cavity deformity (CCD) after cochlear implantation (CI), compare these responses to those in children with normal cochlea, and analyze the influence of cavity volume and electrode position on t...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.70176 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424678348652544 |
|---|---|
| author | Xiuhua Chao Jinye Li Jianfen Luo Xianqi Liu Zhaomin Fan Haibo Wang Lei Xu |
| author_facet | Xiuhua Chao Jinye Li Jianfen Luo Xianqi Liu Zhaomin Fan Haibo Wang Lei Xu |
| author_sort | Xiuhua Chao |
| collection | DOAJ |
| description | ABSTRACT Objectives To investigate neural responsiveness to electrical stimulation in children with common cavity deformity (CCD) after cochlear implantation (CI), compare these responses to those in children with normal cochlea, and analyze the influence of cavity volume and electrode position on these responses. Methods This is a case–control study. Participant included nine children with CCD and 11 children with normal cochlea. For each participant, electrically evoked compound action potentials (ECAPs) were measured, and input/output (I/O) functions were analyzed. The volume of the CCD, electrode to the fundus of the internal auditory canal (E‐IAC) distance, and inner wall (E‐IW) distance were measured on preoperative and postoperative imaging for children with CCD. Linear mixed‐effects models (LMM) explored group differences and the influences of volume, E‐IAC distance, and E‐IW distance on ECAP responses for children with CCD. Results Children with CCD exhibited significantly higher ECAP thresholds and lower amplitudes than those with normal cochlea. The E‐IAC distance has a significant influence on the ECAP threshold and maximum amplitude (ps < 0.05), but no significant effect on the I/O function slopes (p > 0.05). Neither cavity volume nor E‐IW distance had a significant effect on ECAP responses (ps > 0.05). Most children in the CCD group achieved open‐set speech perception, but their word and sentence recognition rates were significantly lower than those in the Control group (ps < 0.01). Conclusion Our findings demonstrated that there were a certain number of residual CNs in children with CCD; however, these nerves exhibited poorer responsiveness to electrical stimulation compared to children with a normal cochlea. Electrodes placed closer to the IAC fundus elicited stronger ECAP responses for children with CCD, which emphasized the importance of surgical strategies that minimize the distance between electrode contacts and residual cochlear nerve structures. Level of Evidence: 3 |
| format | Article |
| id | doaj-art-4bcf82ccb2054c8da2a67d3bb8fd671e |
| institution | Kabale University |
| issn | 2378-8038 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj-art-4bcf82ccb2054c8da2a67d3bb8fd671e2025-08-20T03:30:04ZengWileyLaryngoscope Investigative Otolaryngology2378-80382025-06-01103n/an/a10.1002/lio2.70176Neural Responsiveness to Electrical Stimulation in Children With Common Cavity DeformityXiuhua Chao0Jinye Li1Jianfen Luo2Xianqi Liu3Zhaomin Fan4Haibo Wang5Lei Xu6Department of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaDepartment of Radiology Shandong Second Provincial General Hospital Jinan People's Republic of ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of ChinaABSTRACT Objectives To investigate neural responsiveness to electrical stimulation in children with common cavity deformity (CCD) after cochlear implantation (CI), compare these responses to those in children with normal cochlea, and analyze the influence of cavity volume and electrode position on these responses. Methods This is a case–control study. Participant included nine children with CCD and 11 children with normal cochlea. For each participant, electrically evoked compound action potentials (ECAPs) were measured, and input/output (I/O) functions were analyzed. The volume of the CCD, electrode to the fundus of the internal auditory canal (E‐IAC) distance, and inner wall (E‐IW) distance were measured on preoperative and postoperative imaging for children with CCD. Linear mixed‐effects models (LMM) explored group differences and the influences of volume, E‐IAC distance, and E‐IW distance on ECAP responses for children with CCD. Results Children with CCD exhibited significantly higher ECAP thresholds and lower amplitudes than those with normal cochlea. The E‐IAC distance has a significant influence on the ECAP threshold and maximum amplitude (ps < 0.05), but no significant effect on the I/O function slopes (p > 0.05). Neither cavity volume nor E‐IW distance had a significant effect on ECAP responses (ps > 0.05). Most children in the CCD group achieved open‐set speech perception, but their word and sentence recognition rates were significantly lower than those in the Control group (ps < 0.01). Conclusion Our findings demonstrated that there were a certain number of residual CNs in children with CCD; however, these nerves exhibited poorer responsiveness to electrical stimulation compared to children with a normal cochlea. Electrodes placed closer to the IAC fundus elicited stronger ECAP responses for children with CCD, which emphasized the importance of surgical strategies that minimize the distance between electrode contacts and residual cochlear nerve structures. Level of Evidence: 3https://doi.org/10.1002/lio2.70176cochlear implantationcochlear nervecommon cavity deformityelectrically evoked compound action potential |
| spellingShingle | Xiuhua Chao Jinye Li Jianfen Luo Xianqi Liu Zhaomin Fan Haibo Wang Lei Xu Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity Laryngoscope Investigative Otolaryngology cochlear implantation cochlear nerve common cavity deformity electrically evoked compound action potential |
| title | Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity |
| title_full | Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity |
| title_fullStr | Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity |
| title_full_unstemmed | Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity |
| title_short | Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity |
| title_sort | neural responsiveness to electrical stimulation in children with common cavity deformity |
| topic | cochlear implantation cochlear nerve common cavity deformity electrically evoked compound action potential |
| url | https://doi.org/10.1002/lio2.70176 |
| work_keys_str_mv | AT xiuhuachao neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT jinyeli neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT jianfenluo neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT xianqiliu neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT zhaominfan neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT haibowang neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity AT leixu neuralresponsivenesstoelectricalstimulationinchildrenwithcommoncavitydeformity |