Gut microbial 3α‐hydroxysteroid dehydrogenase promotes depression in males via degrading testosterone

Gut microbial 3α‐hydroxysteroid dehydrogenase promotes depression in males via degrading testosterone

Abstract Abnormal gut microbiota is associated with the occurrence of depression, but the specific pathophysiological role of gut microbiota in the pathogenesis of depression is still unknown. We found that the levels of serum steroid hormone testosterone in male patients with depression were lower...

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Bibliographic Details
Main Authors: Di Li, Jingru Cheng, Wei Zhang, Pengfei Cheng, Yuan He, Jinghan Jia, Chao Wang, Zhongchun Liu, Zhou Sun, Jinxi Wang
Format: Article
Language:English
Published: Wiley-VCH 2025-01-01
Series:Interdisciplinary Medicine
Subjects:
depression
enzyme
gut microbiota
metabolism
testosterone
Online Access:https://doi.org/10.1002/INMD.20240050
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